L1 cell adhesion molecule overexpression in hepatocellular carcinoma associates with advanced tumor progression and poor patient survival.
L1 cell adhesion molecule overexpression in hepatocellular carcinoma associates with advanced tumor progression and poor patient survival.
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DOI：
10.1186/1746-1596-7-96
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发表时间：
2012-08-13
影响因子：
2.6
通讯作者：
Zhao J
中科院分区：
文献类型：
--
作者：
Guo X;Xiong L;Zou L;Sun T;Zhang J;Li H;Peng R;Zhao J
L1细胞黏附分子（L1CAM）作为免疫球蛋白超家族的一员，近期在多种人类恶性肿瘤中被发现。然而，尚无关于肝细胞癌（HCC）中L1CAM的数据。本研究的目的是探讨L1CAM在肝细胞癌中的表达，并确定其与肿瘤进展和预后的相关性。
选取了130例接受了根治性肝切除的肝细胞癌患者，采用免疫组织化学、蛋白质印迹法和实时定量聚合酶链反应（Q - PCR）分析相应肿瘤中L1CAM的表达。
免疫组织化学、蛋白质印迹法和Q - PCR在蛋白质和基因水平均一致证实，与相邻的非肿瘤组织相比，肝细胞癌组织中L1CAM过度表达（均P <0.01）。此外，L1CAM的高表达分别与肿瘤晚期阶段（P = 0.02）和肿瘤高级别（P = 0.03）显著相关。而且，L1CAM高表达的肝细胞癌患者分别与较低的5年总生存率（P <0.01）和较低的5年无病生存率（P <0.01）显著相关。Cox比例风险模型进一步表明，L1CAM过度表达是肝细胞癌5年无病生存率（P = 0.02）和5年总生存率（P = 0.008）的独立不良预后因素。
我们的数据首次表明，肝细胞癌中L1CAM的表达与肿瘤进展晚期显著相关，并且是肝细胞癌患者总生存率和无病生存率的独立不良预后因素。
本文的虚拟切片可在此处找到：http://www.diagnosticpathology.diagnomx.eu/vs/1970024872761542
L1 cell adhesion molecule (L1CAM), as a member of the immunoglobulin superfamily, has recently been observed in a variety of human malignancies. However, no data of L1CAM are available for hepatocellular carcinoma (HCC). The aim of this study was to investigate the expression of L1CAM in HCC and determine its correlation with tumor progression and prognosis. One-hundred and thirty HCC patients who had undergone curative liver resection were selected and immunohistochemistry, Western blotting, and quantitative real time polymerase chain reaction (Q-PCR) were performed to analyze L1CAM expression in the respective tumors. Immunohistochemistry, Western blotting, and Q-PCR consistently confirmed the overexpression of L1CAM in HCC tissues compared with their adjacent nonneoplastic tissues at both protein and gene level (both P <0.01). Additionally, the high expression of L1CAM was significantly associated with advanced tumor stage (P = 0.02) and advanced tumor grade (P = 0.03), respectively. Moreover, HCC patients with high L1CAM expression were significantly associated with lower 5-year overall survival (P <0.01) and lower 5-year disease-free survival (P <0.01), respectively. The Cox proportional hazards model further showed that L1CAM over-expression was an independent poor prognostic factor for both 5-year disease-free survival (P = 0.02) and 5-year overall survival (P = 0.008) in HCC. Our data suggest for the first time that L1CAM expression in HCC was significantly correlated with the advanced tumor progression and was an independent poor prognostic factor for both overall survival and disease-free survival in patients with HCC. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1970024872761542
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