The generation of insulin-like growth factor-1--sensitive cells by growth hormone action.
The generation of insulin-like growth factor-1--sensitive cells by growth hormone action.
复制标题
通过生长激素作用产生胰岛素样生长因子-1 敏感细胞。
作者：
K. M. Zezulak;H. Green
胰岛素样生长因子-1（IGF-1）是一种促有丝分裂多肽，通常被认为是生长激素增加组织质量的唯一效应因子。然而，生长激素，而不是IGF-1，直接促进培养的前脂肪细胞分化为脂肪细胞。新分化的脂肪细胞的前体细胞在生长激素的反应被证明是更敏感的IGF-1比前体细胞的促有丝分裂作用。因此，IGF-1作用的结果是年轻分化细胞的选择性增殖（克隆扩增）。这支持了双重效应系统的概念，其中IGF-1作用的优选靶细胞通过生长激素的直接作用产生。
Insulin-like growth factor-1 (IGF-1), a mitogenic polypeptide, is usually considered the sole effector by means of which growth hormone increases tissue mass. However, growth hormone, but not IGF-1, directly promotes the differentiation of cultured preadipocytes to adipocytes. Adipocytes newly differentiated from precursor cells in response to growth hormone were shown to be much more sensitive to the mitogenic effect of IGF-1 than the precursor cells. The result of IGF-1 action is therefore a selective multiplication of young differentiated cells (cloned expansion). This supports the concept of a dual effector system in which the preferred target cells of IGF-1 action are created by the direct action of growth hormone.
DOI：
10.1016/s0021-9258(18)34631-3
发表时间：
1982-05
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
J. Massagué;M. Czech
通讯作者：
J. Massagué;M. Czech