Optimized analysis of blood flow and wall shear stress in the common carotid artery of rat model by phase-contrast MRI
Optimized analysis of blood flow and wall shear stress in the common carotid artery of rat model by phase-contrast MRI
复制标题
相差MRI对大鼠颈总动脉血流及管壁剪应力的优化分析
作者：
Shin;Cheng;chiun;Shao;Wu
本研究系统地研究了使用相衬磁共振成像（PC-MRI）扫描大鼠颈总动脉（CCA）时，门控/非门控序列、速度编码（VENC）和空间分辨率对血流、壁剪切应力（WSS）和动脉面积评估的影响。我们首先测试了非门控 PC-MRI 是否适合评估大鼠的血流和 WSS。对于门控和非门控技术，还测试了 60-120cm/s 范围内的 VENC 值，间隔为 10cm/s。其次，我们优化了 PC-MRI 血流和 WSS 测量的平面内分辨率。结果表明，使用门控仪器可以提供更具重复性的评估，而 VENC 对所有血流动力学测量结果的影响微不足道（所有 P > 0.05）。较低的分辨率（例如 0.63 mm）会导致血流量和动脉面积量化显着高估，并导致 WSS 测量结果低估（所有 P < 0.05）。然而，0.16 毫米的更高分辨率稍微增加了测量变化。作为准确性和扫描时间之间的权衡，我们提出了一种门控 PC-MRI 序列，其 VENC 为 120 cm/s，分辨率为 0.21 mm，用于提取大鼠 CCA 的血流动力学信息。
The present study systemically investigated the influence of gated/non-gated sequences, velocity encoding (VENC), and spatial resolution on blood flow, wall shear stress (WSS), and artery area evaluations when scanning the common carotid artery (CCA) in rats using phase-contrast magnetic resonance imaging (PC-MRI). We first tested whether or not non-gated PC-MRI was appropriate for evaluating blood flow and WSS in rats. For both gated and non-gated techniques, VENC values in the range of 60–120 cm/s with an interval of 10 cm/s were also tested. Second, we optimized the in-plane resolution of PC-MRI for blood flow and WSS measurements. Results showed the usage of a gated instrument can provide more reproducible assessments, whereas VENC had an insignificant influence on all hemodynamic measurements (all P > 0.05). Lower resolutions, such as 0.63 mm, led to significant overestimations in blood flow and artery area quantifications and to an underestimation in WSS measurements (all P < 0.05). However, a higher resolution of 0.16 mm slightly increased measurement variation. As a tradeoff between accuracy and scan time, we propose a gated PC-MRI sequence with a VENC of 120 cm/s and a resolution of 0.21 mm to be used to extract hemodynamic information about rat CCA.
影响因子：
5.7
作者：
Xu F;Liu P;Pekar JJ;Lu H
通讯作者：
Lu H
影响因子：
4.4
作者：
Strecker, Christoph;Harloff, Andreas;Markl, Michael
通讯作者：
Markl, Michael