Modulation of glucan-binding protein activity in streptococci by fluoride.
Modulation of glucan-binding protein activity in streptococci by fluoride.
复制标题
氟化物对链球菌中葡聚糖结合蛋白活性的调节。
DOI：
10.1016/s0304-4165(00)00024-6
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Doyle,RJ
中科院分区：
文献类型：
--
作者：
Luengpailin,S;Banas,JA;Doyle,RJ
Glucan-binding lectin (GBL) activity of Streptococcus sobrinus was significantly reduced by fluoride in the growth medium. Approximately 1.5 mM fluoride was required for a 50% reduction in GBL activity. In addition to the GBL, several other glucan-binding proteins were reduced when the bacteria were grown in subinhibitory fluoride. Fluoride had no effect on glucosyltransferases (GTFs), enzymes capable of converting sucrose into α-1,6-glucans. All the proteins were detected by use of enhanced chemiluminescence (ECL of fluorescein-labeled dextran) and Western blotting of renatured SDS–PAGE gels. The effects of fluoride on the bacteria were abrogated when the manganous ion was included in the growth medium. It thus appears that one mechanism of action of fluoridated water is its effects on glucan-binding proteins. The fluoride may be reducing metabolism of the mangano aquo ion, essential for expression of the glucan-binding proteins.
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期刊：
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影响因子：
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作者：
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通讯作者：
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