Effects of ethanol, MK-801, and chlordiazepoxide on locomotor activity in different rat lines: dissociation of locomotor stimulation from ethanol preference.
Effects of ethanol, MK-801, and chlordiazepoxide on locomotor activity in different rat lines: dissociation of locomotor stimulation from ethanol preference.
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乙醇、MK-801 和利眠宁对不同大鼠系运动活性的影响：运动刺激与乙醇偏好的分离。
DOI：
10.1111/j.1530-0277.1994.tb00060.x
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Breese,GR
中科院分区：
文献类型：
--
作者：
Criswell,HE;Overstreet,DH;Rezvani,AH;Johnson,KB;Simson,PE;Knapp,DJ;Moy,SS;Breese,GR
多项研究表明药物的奖励价值与其刺激运动的能力之间存在联系。本研究的一个目标是确定乙醇是否优先刺激对乙醇表现出偏好的大鼠系的运动活动。第二个目标是确定乙醇的苯二氮卓类和 NMDA 拮抗作用在多大程度上解释其对运动活动的影响。为了实现这些目标，我们在几组已习惯测试程序的大鼠中研究了不同剂量的乙醇（0.125-1.0 g/kg）、MK-801（0.1-0.3 mg/kg）和利眠宁（0.3-3 mg/kg）对运动活动的影响。低剂量乙醇对酒精偏好（P）和小黄帽大鼠运动活动的影响表现出强烈的乙醇偏好，与酒精不偏好（NP）、弗林德斯敏感系和弗林德斯抵抗系大鼠相似。仅弗林德抗性系大鼠在施用乙醇后表现出小幅但显着的运动活动增加。最高剂量的乙醇（1.0 g/kg）在除 P 和 NP 系之外的所有系中均产生运动抑制，P 和 NP 系未在此剂量下进行测试。这些发现并不支持乙醇运动刺激与乙醇偏好之间的联系。相比之下，所有细胞系在中等剂量（0.1-0.3 mg/kg）MK-801后均表现出运动刺激，但在任何剂量利眠宁后均未表现出活动增加。这些数据表明，在不同的大鼠系中，MK-801 和利眠宁后的活性特征与乙醇不同。因此，乙醇对运动活性的影响不能仅通过其对 NMDA 受体的拮抗剂样作用和/或其对 GABA/苯二氮卓类受体的激动剂样作用来解释。
Several lines of research have suggested a link between the reward value of a drug and its ability to stimulate locomotion. One goal of the present study was to determine whether ethanol preferentially stimulates locomotor activity in lines of rat that show a preference for ethanol. A secondary goal was to determine the extent to which the benzodiazepine‐like and NMDA antagonistic action of ethanol accounted for its effect on locomotor activity. To meet these goals, the effects of varying doses of ethanol (0.125‐1.0 g/kg), MK‐801 (0.1‐0.3 mg/kg), and chlordiazepoxide (0.3‐3 mg/kg) on locomotor activity were studied in several lines of rats that had been habituated to the testing procedure. The effect of low doses of ethanol on motor activity in the Alcohol‐Preferring (P) and Fawn‐Hooded rats, which show a strong ethanol preference, were similar to those of the alcohol‐nonpreferring (NP), Flinders Sensitive Line, and Flinders Resistant Line rats. Only the Flinder Resistant Line rats showed a small, but significant increase in locomotor activity after the administration of ethanol. The highest dose of ethanol (1.0 g/kg) produced locomotor depression in all lines except the P and NP lines, which were not tested at this dose. These findings do not support a link between locomotor stimulation by ethanol and ethanol preference. In contrast, all lines exhibited locomotor stimulation after moderate (0.1‐0.3 mg/kg) doses of MK‐801, but did not exhibit increases in activity following any dose of chlordiazepoxide. These data indicate that the profiles of activity after MK‐801 and chlordiazepoxide were distinct from that of ethanol in the various rat lines. Therefore, the effects of ethanol on locomotor activity cannot be accounted for by reference solely to its antagonist‐like action at NMDA receptors and/or its agonist‐like action at GABA/benzodiazepine receptors.
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乙醇抑制体内 NMDA 诱发的电生理活动。
DOI：
--
发表时间：
1991
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Simson,PE;Criswell,HE;Johnson,KB;Hicks,RE;Breese,GR
通讯作者：
Breese,GR
在大鼠内侧间隔区，乙醇对γ-氨基丁酸介导的神经活动的抑制作用具有位点特异性增强作用。
DOI：
--
发表时间：
1990
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
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作者：
Givens,BS;Breese,GR
通讯作者：
Breese,GR
产后发育过程中个体神经细胞粘附分子多肽的分化依赖性唾液酸化
影响因子：
4.7
作者：
K. Breen;C. Regan
通讯作者：
C. Regan
DOI：
--
发表时间：
1993-05
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
H. Criswell;K. Johnson;R. Mueller;G. Breese
通讯作者：
H. Criswell;K. Johnson;R. Mueller;G. Breese
小鹿罩鼠的遗传性血清素缺乏和酒精偏好。
影响因子：
2.8
作者：
A. Rezvani;D. Overstreet;D. Janowsky
通讯作者：
D. Janowsky