Insights into Inner Ear Function and Disease Through Novel Visualization of the Ductus Reuniens, a Seminal Communication Between Hearing and Balance Mechanisms
Insights into Inner Ear Function and Disease Through Novel Visualization of the Ductus Reuniens, a Seminal Communication Between Hearing and Balance Mechanisms
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通过对留尼恩导管的新颖可视化深入了解内耳功能和疾病，留尼恩导管是听力与平衡机制之间的重要沟通手段
DOI：
10.1007/s10162-022-00858-y
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Laitman, Jeffrey T.
中科院分区：
文献类型：
--
作者：
Smith, Christopher M.;Curthoys, Ian S.;Plontke, Stefan K.;Menzel, Matthias;Mukherjee, Payal;Wong, Christopher;Laitman, Jeffrey T.
哺乳动物内耳中负责听觉和平衡的感觉终末器官通过被称为集合管（也被称为集合管（DR））的小膜管连接。DR通过提供耳蜗和前庭迷路之间的唯一内淋巴连接，作为连接听力和平衡系统的重要纽带。最近的研究已经假设了DR在内耳功能和疾病中的新作用，但是缺乏关于其3D形态和空间配置的知识排除了对这些假设的测试。我们使用四氧化锇微型计算机断层扫描和三个人内耳标本的数字可视化重建了DR和周围解剖结构的3D形态。这提供了DR的形态、与周围结构的空间关系以及其相对于头部位置的取向的估计的详细定量描述。使用软件包3D Slicer和Zbrush进行DR、内耳和颅平面的单变量测量。DR形成一个狭窄、弯曲、扁平的管子，其内腔尺寸、形状和壁厚各不相同，其中中间三分之一最窄。DR在骨螺旋板上级的浅骨沟中延伸，并邻近我们称之为“连合嵴”的骨嵴，该嵴在颅骨内朝向后内侧。DR相对于周围解剖结构的形态和结构配置对于理解内耳功能和疾病的各个方面具有重要意义，特别是在手术改变迷路和梅尼埃病的潜在致病因素之后。
The sensory end-organs responsible for hearing and balance in the mammalian inner ear are connected via a small membranous duct known as the ductus reuniens (also known as the reuniting duct (DR)). The DR serves as a vital nexus linking the hearing and balance systems by providing the only endolymphatic connection between the cochlea and vestibular labyrinth. Recent studies have hypothesized new roles of the DR in inner ear function and disease, but a lack of knowledge regarding its 3D morphology and spatial configuration precludes testing of such hypotheses. We reconstructed the 3D morphology of the DR and surrounding anatomy using osmium tetroxide micro-computed tomography and digital visualizations of three human inner ear specimens. This provides a detailed, quantitative description of the DR’s morphology, spatial relationships to surrounding structures, and an estimation of its orientation relative to head position. Univariate measurements of the DR, inner ear, and cranial planes were taken using the software packages 3D Slicer and Zbrush. The DR forms a narrow, curved, flattened tube varying in lumen size, shape, and wall thickness, with its middle third being the narrowest. The DR runs in a shallow bony sulcus superior to the osseus spiral lamina and adjacent to a ridge of bone that we term the “crista reuniens” oriented posteromedially within the cranium. The DR’s morphology and structural configuration relative to surrounding anatomy has important implications for understanding aspects of inner ear function and disease, particularly after surgical alteration of the labyrinth and potential causative factors for Ménière’s disease.
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DOI：
10.1038/s43856-021-00036-w
发表时间：
2021
期刊：
COMMUNICATIONS MEDICINE
影响因子：
--
作者：
Plontke, Stefan K;Rahne, Torsten;Curthoys, Ian S;Hakansson, Bo;Frohlich, Laura
通讯作者：
Frohlich, Laura
DOI：
--
发表时间：
1982
期刊：
Annals of Otology, Rhinology and Laryngology
影响因子：
--
作者：
I. Curthoys;R. Blanks;C. Markham
通讯作者：
C. Markham
DOI：
--
发表时间：
1982
期刊：
Annals of Otology, Rhinology and Laryngology
影响因子：
--
作者：
K. Kitamura;H. Schuknecht;R. Kimura
通讯作者：
R. Kimura
DOI：
10.1002/ar.24675
发表时间：
2021-06-06
影响因子：
2
作者：
Smith, Christopher M.;Curthoys, Ian S.;Laitman, Jeffrey T.
通讯作者：
Laitman, Jeffrey T.
影响因子：
5.4
作者：
Koeppl, Christine;Manley, Geoffrey A.
通讯作者：
Manley, Geoffrey A.