Infant neural sensitivity to dynamic eye gaze is associated with later emerging autism.
Infant neural sensitivity to dynamic eye gaze is associated with later emerging autism.
复制标题
DOI：
10.1016/j.cub.2011.12.056
复制
发表时间：
2012-02-21
期刊：
影响因子：
--
通讯作者：
BASIS Team
中科院分区：
文献类型：
--
作者：
Elsabbagh M;Mercure E;Hudry K;Chandler S;Pasco G;Charman T;Pickles A;Baron-Cohen S;Bolton P;Johnson MH;BASIS Team
自闭症谱系障碍（以下简称自闭症）在大约1%的人口中被诊断出来。家庭责任赋予风险的一个广泛的困难，包括更广泛的自闭症表型（BAP）。目前还没有可靠的婴儿期自闭症预测指标，但在第二年出现特征性行为，使这个年龄后的诊断成为可能。由于大脑功能的指标可能是敏感的预测因子，而非典型的目光接触是综合征和BAP的特征，我们研究了婴儿期对眼睛凝视的神经敏感性是否与后来的自闭症结果相关。我们对有和没有自闭症家族风险的婴儿进行了一项前瞻性纵向研究。在6 - 10个月时，我们记录了婴儿的事件相关电位（ERP），以响应眼睛注视着婴儿和远离婴儿的面孔。纵向分析表明，在婴儿期对动态眼球凝视转移的反应中诱发的ERP成分的特征与36个月时诊断的自闭症有关。眼睛注视的ERP反应可能有助于描述导致后来出现自闭症的发展过程。研究结果还阐明了婴儿期社会脑发育的驱动机制。·自闭症的家庭风险赋予婴儿大脑功能的微妙差异·婴儿在观看眼睛凝视数据时的非典型ERP与后来的自闭症诊断相关·自闭症的可靠预测需要了解风险和保护因素
Autism spectrum disorders (henceforth autism) are diagnosed in around 1% of the population. Familial liability confers risk for a broad spectrum of difficulties including the broader autism phenotype (BAP). There are currently no reliable predictors of autism in infancy, but characteristic behaviors emerge during the second year, enabling diagnosis after this age. Because indicators of brain functioning may be sensitive predictors, and atypical eye contact is characteristic of the syndrome and the BAP, we examined whether neural sensitivity to eye gaze during infancy is associated with later autism outcomes. We undertook a prospective longitudinal study of infants with and without familial risk for autism. At 6–10 months, we recorded infants' event-related potentials (ERPs) in response to viewing faces with eye gaze directed toward versus away from the infant. Longitudinal analyses showed that characteristics of ERP components evoked in response to dynamic eye gaze shifts during infancy were associated with autism diagnosed at 36 months. ERP responses to eye gaze may help characterize developmental processes that lead to later emerging autism. Findings also elucidate the mechanisms driving the development of the social brain in infancy. ► Family risk for autism confers subtle differences in brain function in infants ► Atypical ERPs in infants when viewing eye gaze data associates with later autism diagnosis ► Robust prediction of autism will require an understanding of risk and protective factors
登录
查看更多内容
影响因子：
3.3
作者：
Johnson, MH;Griffin, R;Richards, J
通讯作者：
Richards, J
影响因子：
10.6
作者：
McCleery JP;Akshoomoff N;Dobkins KR;Carver LJ
通讯作者：
Carver LJ
DOI：
10.1017/s0021963098003035
发表时间：
1998-10-01
期刊：
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES
影响因子：
--
作者：
Leekam, SR;Hunnisett, E;Moore, C
通讯作者：
Moore, C
DOI：
10.1111/j.1469-7610.2009.02153.x
发表时间：
2010-03-01
影响因子：
7.6
作者：
Belmonte, Matthew K.;Gomot, Marie;Baron-Cohen, Simon
通讯作者：
Baron-Cohen, Simon
影响因子：
7.6
作者：
Pickles, A;Starr, E;Rutter, M
通讯作者：
Rutter, M