Atypical face versus object processing and hemispheric asymmetries in 10-month-old infants at risk for autism.
Atypical face versus object processing and hemispheric asymmetries in 10-month-old infants at risk for autism.
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DOI：
10.1016/j.biopsych.2009.07.031
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发表时间：
2009-11-15
影响因子：
10.6
通讯作者：
Carver LJ
中科院分区：
文献类型：
--
作者：
McCleery JP;Akshoomoff N;Dobkins KR;Carver LJ
先前的研究已经记录了患有自闭症谱系障碍（ASD）的儿童和成人在面部/物体处理方面的非典型性。为了调查这种非典型性是否反映了发育早期存在的遗传介导的危险因素，我们测量了 10 个月大的“高危”婴儿的面部/物体处理情况，这些婴儿携带一些与自闭症谱系障碍相关的基因，因为他们有一个年长的兄弟姐妹被诊断出患有这种疾病。我们使用事件相关电位（ERP）来测量皮质对面部和物体图片的反应，这些物体是玩具图片。对 20 名高风险婴儿和 20 名低风险对照（没有 ASD 家族史的婴儿）的四个 ERP 组成部分（P100、N290、P400 和 Nc）的潜伏期和幅度进行了比较。由于 N290 和 P400 的延迟，高风险婴儿和低风险婴儿对面部和物体的反应有所不同。差异的原因是低风险婴儿对面部的反应比高风险婴儿的面部反应更快（P400），相反，高风险婴儿对物体的反应比低风险婴儿的面部反应更快（N290）。而且，高风险婴儿的物体反应比低风险婴儿更快（N290 和 P400）。对于 P100、N290 和 P400 的幅度，高风险婴儿和低风险婴儿的左半球反应与右半球反应也不同。倒在脸部/物体上，低风险，但不是高风险，婴儿表现出半球不对称。自闭症谱系障碍的遗传风险与生命早期非典型的面部与物体处理以及半球不对称的非典型缺乏有关。这些非典型性可能会导致疾病的发展。
Previous studies have documented atypicalities in face/object processing in children and adults with autism spectrum disorders (ASD). To investigate whether such atypicalities may reflect a genetically-mediated risk factor present early in development, we measured face/object processing in 10-month-old “High-Risk” infants, who carry some of the genes associated with ASD because they have an older sibling diagnosed with the disorder. We employed event related potentials (ERPs) to measure cortical responses to pictures of faces and objects, the objects being pictures of toys. Latencies and amplitudes of four ERP components (P100, N290, P400 and Nc) were compared between 20 High-Risk infants and 20 Low-Risk controls (infants with no family history of ASD). Responses to faces vs. objects differed between High- and Low-Risk infants, for the latencies of the N290 and P400. Differences were driven by faster responses to faces than objects in Low-Risk, but not High-Risk, infants (P400), and conversely, faster responses to objects than faces in High-Risk, but not Low-Risk, infants (N290). And, object responses were faster in High-Risk than Low-Risk infants (both N290 and P400). Left vs. right hemisphere responses also differed between High- and Low-Risk infants, for the amplitudes of the P100, N290 and P400; collapsed across faces/objects, Low-Risk, but not High-Risk, infants exhibited hemisphere asymmetries. Genetic risk for ASD is associated with atypical face vs. object processing, and an atypical lack of hemispheric asymmetry, early in life. These atypicalities might contribute to development of the disorder.
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影响因子：
11
作者：
Carver, LJ;Dawson, G
通讯作者：
Dawson, G
影响因子：
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作者：
BAILEY, A;LECOUTEUR, A;RUTTER, M
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RUTTER, M
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作者：
Adolphs, Ralph;Spezio, Michael L.;Parlier, Morgan;Piven, Joseph
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Piven, Joseph
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作者：
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作者：
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