Mini-review: The anti-aging effects of lithium in bipolar disorder.
Mini-review: The anti-aging effects of lithium in bipolar disorder.
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迷你评论：锂在双相情感障碍中的抗衰老作用。
DOI：
10.1016/j.neulet.2021.136051
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发表时间：
2021-08-10
影响因子：
2.5
通讯作者：
Fries GR
中科院分区：
文献类型：
--
作者：
Salarda EM;Zhao NO;Lima CNNC;Fries GR
锂的医疗用途自19世纪首次引入以来一直在增长，用于治疗痛风。今天，二价阳离子仍然是治疗双相情感障碍（BD）的药理学金标准，具有强烈的情绪稳定作用。锂已被证明在治疗急性情感发作、减少情感发作复发和显著降低患者自杀风险方面有效。BD一直与加速老化的临床体征相关，包括年龄相关疾病（如心血管疾病、恶性肿瘤和糖尿病）的发生率增加。这种临床情况与在分子基础上观察到的加速衰老机制相似，研究报告与对照组相比，BD患者端粒缩短，氧化应激增加和表观遗传衰老加速。锂已被证明是一种有效的潜在药物，可减缓BD的加速老化过程，可能逆转由疾病引起的效应。这篇小型评论总结了与锂使用相关的抗衰老机制的发现，并讨论了这一不断发展的领域的临床意义和前景。尽管有许多有希望的结果，更多的研究是必要的，以阐明锂可以作为一种抗衰老剂的确切机制，以及这些机制在多大程度上与其在BD中的情绪稳定特性有关。
The medical use of lithium has grown since its initial introduction in the 1800s as a treatment for gout. Today, the divalent cation remains as the pharmacological gold standard in treatment of bipolar disorder (BD) with strong mood stabilizing effects. Lithium has demonstrated efficacy in the treatment of acute affective episodes, in the reduction of affective episode recurrence, and in significantly decreasing the risk of suicide in patients. BD has been consistently associated with clinical signs of accelerated aging, including increased rates of age-related diseases such as cardiovascular diseases, malignancies, and diabetes mellitus. This clinical scenario parallels accelerated aging mechanisms observed on a molecular basis, with studies reporting shortened telomeres, increased oxidative stress, and accelerated epigenetic aging in patients with BD compared to controls. Lithium has proved useful as a potential agent in slowing down this accelerated aging process in BD, potentially reversing effects induced by the disorder. This mini review summarizes findings of anti-aging mechanisms associated with lithium use and provides a discussion of the clinical implications and perspectives of this evolving field. Despite many promising results, more studies are warranted in order to elucidate the exact mechanism by which lithium may act as an anti-aging agent and the extent to which these mechanisms are relevant to its mood stabilizing properties in BD.
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DOI：
10.1159/000430867
发表时间：
2015-07-01
期刊：
Molecular neuropsychiatry
影响因子：
--
作者：
Backlund, Lena;Wei, Ya Bin;Lavebratt, Catharina
通讯作者：
Lavebratt, Catharina
影响因子：
3.4
作者：
de Sousa, Rafael T.;Streck, Emilio L.;Machado-Vieira, Rodrigo
通讯作者：
Machado-Vieira, Rodrigo
DOI：
10.1016/s0140-6736(16)00143-4
发表时间：
2016-03-12
期刊：
Lancet (London, England)
影响因子：
--
作者：
Hou L;Heilbronner U;Degenhardt F;Adli M;Akiyama K;Akula N;Ardau R;Arias B;Backlund L;Banzato CEM;Benabarre A;Bengesser S;Bhattacharjee AK;Biernacka JM;Birner A;Brichant-Petitjean C;Bui ET;Cervantes P;Chen GB;Chen HC;Chillotti C;Cichon S;Clark SR;Colom F;Cousins DA;Cruceanu C;Czerski PM;Dantas CR;Dayer A;Étain B;Falkai P;Forstner AJ;Frisén L;Fullerton JM;Gard S;Garnham JS;Goes FS;Grof P;Gruber O;Hashimoto R;Hauser J;Herms S;Hoffmann P;Hofmann A;Jamain S;Jiménez E;Kahn JP;Kassem L;Kittel-Schneider S;Kliwicki S;König B;Kusumi I;Lackner N;Laje G;Landén M;Lavebratt C;Leboyer M;Leckband SG;Jaramillo CAL;MacQueen G;Manchia M;Martinsson L;Mattheisen M;McCarthy MJ;McElroy SL;Mitjans M;Mondimore FM;Monteleone P;Nievergelt CM;Nöthen MM;Ösby U;Ozaki N;Perlis RH;Pfennig A;Reich-Erkelenz D;Rouleau GA;Schofield PR;Schubert KO;Schweizer BW;Seemüller F;Severino G;Shekhtman T;Shilling PD;Shimoda K;Simhandl C;Slaney CM;Smoller JW;Squassina A;Stamm T;Stopkova P;Tighe SK;Tortorella A;Turecki G;Volkert J;Witt S;Wright A;Young LT;Zandi PP;Potash JB;DePaulo JR;Bauer M;Reininghaus EZ;Novák T;Aubry JM;Maj M;Baune BT;Mitchell PB;Vieta E;Frye MA;Rybakowski JK;Kuo PH;Kato T;Grigoroiu-Serbanescu M;Reif A;Del Zompo M;Bellivier F;Schalling M;Wray NR;Kelsoe JR;Alda M;Rietschel M;McMahon FJ;Schulze TG
通讯作者：
Schulze TG
影响因子：
11.4
作者：
CADE, JFJ
通讯作者：
CADE, JFJ
影响因子：
4.8
作者：
Fries, Gabriel R.;Zamzow, Madeline J.;Walss-Bass, Consuelo
通讯作者：
Walss-Bass, Consuelo