Pregnancy outcomes in women with thalassemia in North America and the United Kingdom.
Pregnancy outcomes in women with thalassemia in North America and the United Kingdom.
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DOI：
10.1002/ajh.23506
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发表时间：
2013-09
影响因子：
12.8
通讯作者：
Kwiatkowski, Janet L.
中科院分区：
文献类型：
--
作者：
Thompson, Alexis A.;Kim, Hae-Young;Singer, Sylvia T.;Vichinsky, Elliott;Eile, Jennifer;Yamashita, Robert;Giardina, Patricia J.;Olivieri, Nancy;Parmar, Nagina;Trachtenberg, Felicia;Neufeld, Ellis J.;Kwiatkowski, Janet L.
地中海贫血患者生存率的提高使人们重新关注生活质量，包括计划生育。了解与不孕症和不良妊娠结局相关的问题可能会影响地中海贫血患者的临床护理。我们报告了地中海贫血临床研究网络 (TCRN) 登记处登记的受试者的怀孕数量和结果，并检查与成功分娩相关的变量。我们在数据集中的 264 名年龄为 18 岁或以上的女性中确定了 72 名女性的 129 次怀孕。超过 70% 的妊娠产生了活产，73/83 (88%) 的活产发生在足月。大多数怀孕（78.2%）是在没有生殖技术的情况下受孕的。大多数（59.3%）怀孕发生在长期输血计划期间，但只有 38.9% 接受铁螯合治疗。四名女性出现了心脏病。已怀孕女性的铁负荷与年龄和诊断匹配的从未怀孕的对照组没有显着差异。与诊断、输血状态、糖尿病或丙型肝炎感染相关的妊娠结局也没有差异。在 TCRN 登记处，27.3% 的育龄期地中海贫血女性怀孕，这比我们之前 2004 年的报告显着增加。通过最佳的健康维护，成功怀孕是可以实现的。是。 J.赫马托尔。 88:771–773, 2013。© 2013 Wiley periodicals, Inc.
Improved survival in thalassemia has refocused attention on quality of life, including family planning. Understanding the issues associated with infertility and adverse pregnancy outcomes may impact clinical care of patients with thalassemia. We report the number and outcomes of pregnancies among subjects enrolled in Thalassemia Clinical Research Network (TCRN) registries and examine variables associated with successful childbirth. We identified 129 pregnancies in 72 women among the 264 women, age 18 years or older in our dataset. Over 70% of pregnancies resulted in live births and 73/83 (88%) of live births occurred at full term. Most pregnancies (78.2%) were conceived without reproductive technologies. Most (59.3%) pregnancies occurred while on chronic transfusion programs, however only 38.9% were on iron chelation. Four women developed heart problems. Iron burden in women who had conceived was not significantly different from age‐ and diagnosis‐matched controls that had never been pregnant. There was also no difference in pregnancy outcomes associated with diagnosis, transfusion status, diabetes or Hepatitis C infection. Pregnancies occurred in 27.3% of women with thalassemia of child‐bearing age in the TCRN registries, a notable increase from our previous 2004 report. With optimal health maintenance, successful pregnancies may be achievable. Am. J. Hematol. 88:771–773, 2013. © 2013 Wiley Periodicals, Inc.
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影响因子：
1
作者：
Bajoria, Rekha;Chatterjee, Ratna
通讯作者：
Chatterjee, Ratna
DOI：
10.1111/j.1749-6632.2010.05583.x
发表时间：
2010-01-01
期刊：
COOLEY'S ANEMIA: NINTH SYMPOSIUM
影响因子：
--
作者：
Singer, Sylvia T.;Sweeters, Nancy;Cedars, Marcelle
通讯作者：
Cedars, Marcelle
影响因子：
20.3
作者：
Kwiatkowski, Janet L.;Kim, Hae-Young;Neufeld, Ellis J.
通讯作者：
Neufeld, Ellis J.
影响因子：
20.3
作者：
Cunningham, MJ;Macklin, EA;Cohen, AR
通讯作者：
Cohen, AR
影响因子：
1
作者：
Tsironi, Maria;Karagiorga, Markissia;Aessopos, Athanasios
通讯作者：
Aessopos, Athanasios