Assessment of right ventricular oxidative metabolism by positron emission tomography with C-11 acetate in aortic valve disease.
Assessment of right ventricular oxidative metabolism by positron emission tomography with C-11 acetate in aortic valve disease.
复制标题
使用 C-11 醋酸盐进行正电子发射断层扫描评估主动脉瓣疾病中的右心室氧化代谢。
DOI：
10.1016/0002-9149(91)90535-s
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Schwaiger,M
中科院分区：
文献类型：
--
作者：
Hicks,RJ;Kalff,V;Savas,V;Starling,MR;Schwaiger,M
Evaluation of right ventricular (RV) oxidative metabolism is limited by the inability to easily determine oxygen extraction by the RV myocardium and the complex morphology of this ventricle. Because left ventricular C-11 clearance rate constants closely correlate with myocardial oxygen consumption, it was postulated that C-11 clearance rate constants for the RV free wall should also reflect its oxygen consumption. Therefore, RV C-11 clearance rate constants were compared with RV loading in 21 patients with aortic valve disease to assess the possible use of this technique for noninvasive evaluation of RV oxidative metabolism. RV free wall C-11 clearance rate constants correlated with the product of systolic pulmonary artery pressure and heart rate for all patients (r = 0.65, p = 0.002), but the relation was stronger if 2 patients with overt RV dysfunction were excluded (r = 0.83, p = 0.001). On the basis of mean pulmonary artery pressures, patients were stratified into subgroups with normal (group I, n = 8) and elevated (group II, n = 13) pulmonary pressures and were compared with 10 normal control subjects. RV C-11 clearance rate constants were significantly higher in group II than in group I and in normal control subjects (p < 0.05). These data suggest that RV C-11 acetate clearance rate constants can provide noninvasive evaluation of RV oxidative metabolism. This technique may allow serial assessment of RV performance in various cardiac and pulmonary diseases, and particularly of changes associated with therapeutic interventions.
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用醋酸碳 11 和正电子发射断层扫描对犬心肌氧化代谢进行无创评估。
影响因子：
24
作者：
Brown,MA;Myears,DW;Bergmann,SR
通讯作者：
Bergmann,SR
使用[1-11C]乙酸盐和动态正电子发射断层扫描对体内局部心肌耗氧量进行无创定量。
影响因子：
37.8
作者：
Buxton,DB;Nienaber,CA;Luxen,A;Ratib,O;Hansen,H;Phelps,ME;Schelbert,HR
通讯作者：
Schelbert,HR
右心室功能：无创闪烁扫描评估的方法学和临床考虑。
影响因子：
24
作者：
B. Manno;A. Iskandrian;A. Hakki
通讯作者：
A. Hakki
DOI：
10.1152/ajplegacy.1976.231.5.1395
发表时间：
1976
期刊：
The American journal of physiology
影响因子：
--
作者：
R. Raines;M. LeWinter;J. Covell
通讯作者：
J. Covell
对伴或不伴右心室功能障碍的下壁心肌梗死患者进行前瞻性临床、闪烁扫描、血管造影和功能评估。
影响因子：
24
作者：
D. E. Haines;G. Beller;D. Watson;T. Nygaard;G. B. Craddock;Ann A. Cooper;R. Gibson
通讯作者：
R. Gibson