High-throughput rheology in a microfluidic device.
High-throughput rheology in a microfluidic device.
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微流体装置中的高通量流变学。
作者：
Kelly M. Schultz;E. Furst
展示了在微流控装置中进行的高通量流变学测量。使用微流控T形结在不相容的间隔液中以液滴的形式产生一系列微流变样品。样品液滴的组成在很大范围内连续变化。使用多粒子跟踪微观流变学在每个液滴中进行流变学测量。我们回顾了关键的设计和操作参数，包括液滴大小、流速和快速制造方法。验证实验是通过测量甘油和生物聚合物肝素的溶液粘度作为浓度的函数进行的。总体而言，微流变学与微流变学的结合最大限度地增加了流变学测量的次数，同时最大限度地减少了样品制备时间和材料的量，特别适用于稀缺或昂贵材料的表征。
High-throughput rheological measurements in a microfluidic device are demonstrated. A series of microrheology samples are generated as droplets in an immiscible spacer fluid using a microfluidic T-junction. The compositions of the sample droplets are continuously varied over a wide range. Rheology measurements are made in each droplet using multiple particle tracking microrheology. We review critical design and operating parameters, including the droplet size, flow rates and rapid fabrication methods. Validation experiments are performed by measuring the solution viscosity of glycerine and the biopolymer heparin as a function of concentration. Overall, the combination of microrheology with microfluidics maximizes the number of rheological measurements while simultaneously minimizing the sample preparation time and amount of material, and should be particularly suited to the characterization of scarce or expensive materials.
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影响因子：
9.7
作者：
Nie, Ting;Akins, Robert E., Jr.;Kiick, Kristi L.
通讯作者：
Kiick, Kristi L.
影响因子：
3.4
作者：
Schultz KM;Baldwin AD;Kiick KL;Furst EM
通讯作者：
Furst EM
影响因子：
10.8
作者：
Nie, Ting;Baldwin, Aaron;Kiick, Kristi L.
通讯作者：
Kiick, Kristi L.
影响因子：
16.6
作者：
Song, H;Tice, JD;Ismagilov, RF
通讯作者：
Ismagilov, RF
影响因子：
14
作者：
Benoit, Danielle S. W.;Durney, Andrew R.;Anseth, Krish S.
通讯作者：
Anseth, Krish S.