Fertility Sparing Treatments in Endometrial Cancer Patients: The Potential Role of the New Molecular Classification.
Fertility Sparing Treatments in Endometrial Cancer Patients: The Potential Role of the New Molecular Classification.
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DOI：
10.3390/ijms222212248
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发表时间：
2021-11-12
影响因子：
5.6
通讯作者：
Signore F
中科院分区：
文献类型：
--
作者：
Cavaliere AF;Perelli F;Zaami S;D'Indinosante M;Turrini I;Giusti M;Gullo G;Vizzielli G;Mattei A;Scambia G;Vidiri A;Signore F
子宫内膜癌是最常见的妇科恶性肿瘤，虽然在流行病学上它主要影响高龄妇女，但它也可以影响想要孩子和尚未完成生育计划的年轻患者。生育保留治疗是许多研究和研究的主题，并在不断发展，并代表了希望之光的年轻癌症患者发现自己不得不面对肿瘤学的道路之前，实现自己的母亲的愿望。分子生物学的进步以及基于2013年癌症基因组图谱分类的子宫内膜癌更精确的临床和预后分类允许选择可以接受生育保留治疗的患者，同时增加肿瘤安全性。通过研究错配修复基因的状态，也有可能预测对激素治疗的反应。
Endometrial cancer is the most frequent gynecological malignancy, and, although epidemiologically it mainly affects advanced age women, it can also affect young patients who want children and who have not yet completed their procreative project. Fertility sparing treatments are the subject of many studies and research in continuous evolution, and represent a light of hope for young cancer patients who find themselves having to face an oncological path before fulfilling their desire for motherhood. The advances in molecular biology and the more precise clinical and prognostic classification of endometrial cancer based on the 2013 The Cancer Genome Atlas classification allow for the selection of patients who can be submitted to fertility sparing treatments with increasing oncological safety. It would also be possible to predict the response to hormonal treatment by investigating the state of the genes of the mismatch repair.
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DOI：
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发表时间：
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影响因子：
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作者：
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影响因子：
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