In vivo spatiotemporal dynamics of astrocyte reactivity following neural electrode implantation.
In vivo spatiotemporal dynamics of astrocyte reactivity following neural electrode implantation.
复制标题
神经电极植入后星形胶质细胞反应的在体时空动力学。
DOI：
10.1016/j.biomaterials.2022.121784
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发表时间：
2022-10
期刊：
影响因子：
14
通讯作者：
中科院分区：
文献类型：
--
作者：
脑机接口（BCIs），包括穿透性微电极阵列，可以记录和刺激神经细胞。然而，设备植入不可避免地会造成脑组织损伤并诱发异物反应，导致记录性能和刺激效果下降。健康大脑中的星形胶质细胞发挥多种作用，包括调节能量代谢、稳态平衡、神经信号传输和神经血管耦合。大脑受到损伤后，它们会被激活并聚集在受伤部位周围。这些反应性星形胶质细胞被认为是影响微电极阵列性能的神经胶质疤痕形成的主要因素之一。本研究使用双光子显微镜研究了将皮质内微电极植入小鼠大脑后的前两周内星形胶质细胞的动态。根据我们的观察，星形胶质细胞在此期间高度动态，表现出过程延伸、体细胞迁移、形态激活和装置封装的模式，这些模式在时空上与其他神经胶质细胞（例如小胶质细胞或少突胶质细胞前体细胞）不同。星形胶质细胞反应性的详细表征将有助于更好地了解组织对皮质内装置的反应，并导致开发更有效的干预策略，以提高神经接口技术的功能性能。
Brain computer interfaces (BCIs), including penetrating microelectrode arrays, enable both recording and stimulation of neural cells. However, device implantation inevitably causes injury to brain tissue and induces a foreign body response, leading to reduced recording performance and stimulation efficacy. Astrocytes in the healthy brain play multiple roles including regulating energy metabolism, homeostatic balance, transmission of neural signals, and neurovascular coupling. Following an insult to the brain, they are activated and gather around the site of injury. These reactive astrocytes have been regarded as one of the main contributors to the formation of a glial scar which affects the performance of microelectrode arrays. This study investigates the dynamics of astrocytes within the first 2 weeks after implantation of an intracortical microelectrode into the mouse brain using two-photon microscopy. From our observation astrocytes are highly dynamic during this period, exhibiting patterns of process extension, soma migration, morphological activation, and device encapsulation that are spatiotemporally distinct from other glial cells, such as microglia or oligodendrocyte precursor cells. This detailed characterization of astrocyte reactivity will help to better understand the tissue response to intracortical devices and lead to the development of more effective intervention strategies to improve the functional performance of neural interfacing technology.
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影响因子：
4
作者：
Chestek CA;Gilja V;Nuyujukian P;Foster JD;Fan JM;Kaufman MT;Churchland MM;Rivera-Alvidrez Z;Cunningham JP;Ryu SI;Shenoy KV
通讯作者：
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影响因子：
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通讯作者：
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通讯作者：
Kipp, Markus
影响因子：
3.4
作者：
Araque, A;Parpura, V;Haydon, PG
通讯作者：
Haydon, PG