Long-term stability of neural prosthetic control signals from silicon cortical arrays in rhesus macaque motor cortex.
Long-term stability of neural prosthetic control signals from silicon cortical arrays in rhesus macaque motor cortex.
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DOI：
10.1088/1741-2560/8/4/045005
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发表时间：
2011-08
影响因子：
4
通讯作者：
Shenoy KV
中科院分区：
文献类型：
--
作者：
Chestek CA;Gilja V;Nuyujukian P;Foster JD;Fan JM;Kaufman MT;Churchland MM;Rivera-Alvidrez Z;Cunningham JP;Ryu SI;Shenoy KV
皮质控制假肢系统旨在通过将来自大脑的神经信号转换为控制信号来指导假肢设备，从而帮助残疾患者。最近的报告表明，计算机光标和假肢具有相当高的性能和控制水平，但要实现真正的临床可行性，必须更好地了解这些系统的长期运行。特别是，电记录的神经信号的质量和稳定性需要进一步的表征。在这里，我们从3个动物的4个皮质内阵列记录了382天的动作电位变化和离线神经译码性能。在9.4、10.4和31.7个月的病程中，3只动物的动作电位波幅平均每月下降2.4%。在大多数时间段，解码器的性能与动作电位幅度没有很好的相关性(p>；4个阵列中的3个)。在同一动物的两个阵列中，动作电位幅度在植入后的前2个月平均下降了37%。然而，当使用简单的阈值跨越事件而不是良好隔离的动作电位时，在使用离线解码器期间没有观察到相应的性能损失。其中一个阵列在接下来的一年里被有效地用于在线假肢实验。使用无线系统对一只动物的连续记录进行量化，并在一天内和两天之间比较所有三种动物的波形的显著短期变化。总体而言，这项研究表明，动作电位幅度下降的速度比之前假设的要慢，当从阈值跨越事件而不是孤立的动作电位解码时，性能可以在多年的过程中保持。这表明，神经假体系统可能在多年的人类临床试验中提供高性能。
Cortically-controlled prosthetic systems aim to help disabled patients by translating neural signals from the brain into control signals for guiding prosthetic devices. Recent reports have demonstrated reasonably high levels of performance and control of computer cursors and prosthetic limbs, but to achieve true clinical viability the long-term operation of these systems must be better understood. In particular, the quality and stability of the electrically-recorded neural signals requires further characterization. Here, we quantify action potential changes and offline neural decoder performance over 382 days of recording from 4 intracortical arrays in 3 animals. Action potential amplitude decreased by 2.4% per month on average over the course of 9.4, 10.4, and 31.7 months in 3 animals. During most time periods, decoder performance was not well correlated with action potential amplitude (p > 0.05 for 3 of 4 arrays). In two arrays from one animal, action potential amplitude declined by an average of 37% over the first 2 months after implant. However, when using simple threshold crossing events rather than well isolated action potentials, no corresponding performance loss was observed during this time using an offline decoder. One of these arrays was effectively used for online prosthetic experiments over the following year. Substantial short-term variations in waveforms were quantified using a wireless system for contiguous recording in one animal, and compared within and between days for all three animals. Overall, this study suggests that action potential amplitude declines more slowly than previously supposed, and performance can be maintained over the course of multiple years when decoding from threshold crossing events rather than isolated action potentials. This suggests that neural prosthetic systems may provide high performance over multiple years in human clinical trials.
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偏差，最佳线性估计以及基于峰值的大脑计算机界面算法的开环模拟与闭环性能之间的差异。
DOI：
10.1016/j.neunet.2009.05.005
发表时间：
2009-11
期刊：
Neural networks : the official journal of the International Neural Network Society
影响因子：
--
作者：
Chase SM;Schwartz AB;Kass RE
通讯作者：
Kass RE
DOI：
10.1109/tnsre.2009.2023293
发表时间：
2009-08-01
影响因子：
4.9
作者：
Chestek, Cynthia A.;Gilja, Vikash;Shenoy, Krishna V.
通讯作者：
Shenoy, Krishna V.
影响因子：
4.1
作者：
Blakely, Tim;Miller, Kai J.;Ojemann, Jeffrey G.
通讯作者：
Ojemann, Jeffrey G.
影响因子：
9.8
作者：
Ganguly K;Carmena JM
通讯作者：
Carmena JM
影响因子：
4
作者：
Acharya S;Fifer MS;Benz HL;Crone NE;Thakor NV
通讯作者：
Thakor NV