The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress.
The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress.
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microRNA-200c 在阿尔茨海默病病理学中的保护作用是由 β 淀粉样蛋白触发的内质网应激诱导的。
DOI：
10.3389/fnmol.2016.00140
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发表时间：
2016
影响因子：
4.8
通讯作者：
Wan J
中科院分区：
文献类型：
--
作者：
Wu Q;Ye X;Xiong Y;Zhu H;Miao J;Zhang W;Wan J
MicroRNA是一种抑制靶蛋白表达的非编码小RNA。microRNA在阿尔茨海默病（AD）发生发展中的作用尚不清楚。在这项研究中，我们发现miR-200 c抑制PTEN蛋白的表达。通过miR-200 c下调PTEN支持培养的神经元的存活和分化。AD是一种进行性神经退行性疾病，以β淀粉样蛋白（Aβ）肽聚集和沉积为标志。在由APPswe和PS1ΔE9双转基因诱导的AD小鼠模型中，我们发现Aβ沉积导致神经元ER应激，从而诱导miR 200 c。药物阻断ER应激可抑制AD脑中Aβ诱导的miR-200 c过表达。在AD小鼠和人AD患者的血清中检测到miR-200 c。这些发现表明，miR-200 c作为神经元细胞内在适应机制的一部分发挥作用，并通过下调PTEN支持神经元对Aβ诱导的ER应激的存活和分化。
MicroRNAs are small non-coding RNAs that repress the expression of their target proteins. The roles of microRNAs in the development of Alzheimer's disease (AD) are not clear. In this study we show that miR-200c represses the expression of PTEN protein. PTEN downregulation by miR-200c supports the survival and differentiation of cultured neurons. AD is a progressive neurodegenerative disease signified by beta amyloid (Aβ) peptide aggregation and deposition. In a mouse model of AD that is induced by APPswe and PS1ΔE9 double transgenes, we found Aβ deposition results in neuronal ER stress that induces miR200c. Pharmacological blockade of ER stress inhibited Aβ-induced miR-200c overexpression in AD brains. MiR-200c was detected in the serum of both AD mice and human AD patients. These findings suggest that miR-200c functions as part of the neuronal cell-intrinsic adaptive machinery, and supports neuronal survival and differentiation in response to Aβ induced ER-stress by downregulating PTEN.
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影响因子：
3.3
作者：
Fraser, M. M.;Bayazitov, I. T.;Baker, S. J.
通讯作者：
Baker, S. J.
DOI：
10.1016/s1050-3862(96)00167-2
发表时间：
1996-12-01
期刊：
GENETIC ANALYSIS-BIOMOLECULAR ENGINEERING
影响因子：
--
作者：
Borchelt, DR;Davis, J;Price, DL
通讯作者：
Price, DL
影响因子：
25
作者：
Knafo, Shira;Sanchez-Puelles, Cristina;Esteban, Jose A.
通讯作者：
Esteban, Jose A.
影响因子：
10.6
作者：
Rattray, M
通讯作者：
Rattray, M
影响因子：
3.4
作者：
Li, Baoguo;Sun, Hanxiao
通讯作者：
Sun, Hanxiao