Runx3 Mediates Resistance to Intracellular Bacterial Infection by Promoting IL12 Signaling in Group 1 ILC and NCR+ILC3.
Runx3 Mediates Resistance to Intracellular Bacterial Infection by Promoting IL12 Signaling in Group 1 ILC and NCR+ILC3.
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Runx3 通过促进第 1 组 ILC 和 NCR ILC3 中的 IL12 信号传导介导对细胞内细菌感染的抵抗力
DOI：
10.3389/fimmu.2018.02101
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发表时间：
2018
影响因子：
7.3
通讯作者：
Wang L
中科院分区：
文献类型：
--
作者：
Yin S;Yu J;Hu B;Lu C;Liu X;Gao X;Li W;Zhou L;Wang J;Wang D;Lu L;Wang L
天然淋巴样细胞(ILCs)是最新发现的天然免疫系统家族，被认为在产生适应性免疫反应之前调节免疫功能。ILC的亚群存在于粘膜中，调节对外部病原体的免疫反应；然而，它们的作用和保护细胞内细菌感染的机制尚不完全清楚。用鼠伤寒沙门氏菌和单核细胞增生性沙门氏菌，我们发现感染后第1组ILCs和NCR+ILC3s的水平增加，并且这些增加与Run相关转录因子3(Runx3)的表达有关。RUNX3 fl/fl PLZF-cre小鼠对细胞内致病菌鼠伤寒沙门氏菌和单核细胞增多性沙门氏菌的感染更为敏感，部分原因是第1组ILC和NCR+ILC3功能异常。我们还发现，Runx3直接与IL12Rβ2启动子和内含子8结合，加速IL12Rβ2的表达，并调节IL12/STAT4轴触发的干扰素γ的分泌。因此，我们证明Runx3影响第1组ILC和NCR+ILC3介导的免疫保护，以对抗肠道和肝脏的细胞内细菌感染。
Innate lymphoid cells (ILCs) are the most recently identified family of the innate immune system and are hypothesized to modulate immune functions prior to the generation of adaptive immune responses. Subsets of ILCs reside in the mucosa and regulate immune responses to external pathogens; however, their role and the mechanism by which they protect against intracellular bacterial infection is not completely understood. In this report, using S. typhimurium and L. monocytogenes, we found that the levels of group 1 ILCs and NCR+ ILC3s were increased upon infection and that these increases were associated with Runt-related transcription factor 3 (Runx3) expression. Runx3 fl/fl PLZF-cre mice were much more sensitive to infection with the intracellular bacterial pathogens S. typhimurium and L. monocytogenes partially due to abnormal Group 1 ILC and NCR+ILC3 function. We also found that Runx3 directly binds to the Il12Rβ2 promoter and intron 8 to accelerate the expression of Il12Rβ2 and modulates IFNγ secretion triggered by the IL12/ STAT4 axis. Therefore, we demonstrate that Runx3 influences group 1 ILC- and NCR+ILC3-mediated immune protection against intracellular bacterial infections of both the gut and liver.
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视黄酸差异调节先天淋巴细胞亚群向肠道的迁移。
影响因子：
32.4
作者：
Kim MH;Taparowsky EJ;Kim CH
通讯作者：
Kim CH
影响因子：
30.5
作者：
通讯作者：
--
上皮内膜IKKα表达调节3组先天淋巴样细胞反应和抗菌免疫。
DOI：
10.1084/jem.20141831
发表时间：
2015-09-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Giacomin PR;Moy RH;Noti M;Osborne LC;Siracusa MC;Alenghat T;Liu B;McCorkell KA;Troy AE;Rak GD;Hu Y;May MJ;Ma HL;Fouser LA;Sonnenberg GF;Artis D
通讯作者：
Artis D
影响因子：
32.4
作者：
Guo, Xiaohuan;Qiu, Ju;Tu, Tony;Yang, Xuanming;Deng, Liufu;Anders, Robert A.;Zhou, Liang;Fu, Yang-Xin
通讯作者：
Fu, Yang-Xin
影响因子：
3.7
作者：
Lotem J;Levanon D;Negreanu V;Leshkowitz D;Friedlander G;Groner Y
通讯作者：
Groner Y