Lysine Inhibits Hemolytic Activity of Staphylococcus aureus and Its Application in Food Model Contaminated with Staphylococcus aureus.
Lysine Inhibits Hemolytic Activity of Staphylococcus aureus and Its Application in Food Model Contaminated with Staphylococcus aureus.
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赖氨酸抑制金黄色葡萄球菌溶血活性及其在金黄色葡萄球菌污染食品模型中的应用
DOI：
10.3390/toxins14120867
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发表时间：
2022-12-09
期刊：
影响因子：
4.2
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Wan Y;Wang X;Bai T;Zheng X;Yang L;Li Q;Wang X
Highlights What are the main findings? Lysine inhibits hemolytic activity of S. aureus; Lysine inhibits the expression of toxin Hla of S. aureus; Lysine inhibits Hla oligomerization; Lysine attenuates S. aureus supernatant damage in mice and Caco-2 cells; Lysine inhibits the expression of Hla of S. aureus in a food model and had good biocompatibility. What is the implication of the main finding? Lysine has the potential to be used as an anti- S. aureus preparation in the food industry. Abstract Alpha-hemolysin (Hla) is one of the important exotoxins of Staphylococcus aureus (S. aureus) and can be used as a target to reduce the virulence of S. aureus. This study explored the inhibitory effect of Lysine (Lys) on Hla and its application in food safety. Lys significantly inhibited the expression of Hla at sub-inhibitory concentrations and directly interacted with Hla to interfere with its oligomerization and thus significantly inhibited its hemolytic activity. Notably, Lys attenuated S. aureus damage to mouse small intestine and Caco-2 cells and delayed mouse mortality. In the food model, Lys inhibited the expression of Hla of S. aureus and had no significant effect on the sensory score. Moreover, Lys had no obvious damage effect on the main organs of mice, which indicated that Lys has good biocompatibility and has the potential to be used in the food industry as an anti-S. aureus preparation.
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影响因子：
2.8
作者：
Johny, Anup Kollanoor;Hoagland, Thomas;Venkitanarayanan, Kumar
通讯作者：
Venkitanarayanan, Kumar
影响因子：
4.5
作者：
Squier, C;Rihs, JD;Singh, N
通讯作者：
Singh, N
影响因子：
6.4
作者：
Qiu, Jiazhang;Niu, Xiaodi;Deng, Xuming
通讯作者：
Deng, Xuming
DOI：
10.1128/cvi.00091-16
发表时间：
2016-06
期刊：
Clinical and vaccine immunology : CVI
影响因子：
--
作者：
Fiaschi L;Di Palo B;Scarselli M;Pozzi C;Tomaszewski K;Galletti B;Nardi-Dei V;Arcidiacono L;Mishra RP;Mori E;Pallaoro M;Falugi F;Torre A;Fontana MR;Soriani M;Bubeck Wardenburg J;Grandi G;Rappuoli R;Ferlenghi I;Bagnoli F
通讯作者：
Bagnoli F
影响因子：
3.7
作者：
Tkaczyk C;Hamilton MM;Datta V;Yang XP;Hilliard JJ;Stephens GL;Sadowska A;Hua L;O'Day T;Suzich J;Stover CK;Sellman BR
通讯作者：
Sellman BR