Salmonella polarises peptide-MHC-II presentation towards an unconventional Type B CD4+ T-cell response.
Salmonella polarises peptide-MHC-II presentation towards an unconventional Type B CD4+ T-cell response.
复制标题
DOI：
10.1002/eji.201242983
复制
发表时间：
2013-04
影响因子：
5.4
通讯作者：
Kelly, Adrian P.
中科院分区：
文献类型：
--
作者：
Jackson, Nicola P.;Kang, Yu Hui;Lapaque, Nicolas;Janssen, Hans;Trowsdale, John;Kelly, Adrian P.
当抗原加载到不同的细胞内区室时，产生由A型和B型CD 4 + T细胞亚群识别的不同的肽-MHC-II复合物。常规的A型T细胞识别它们的肽表位而不管加工途径如何，而非常规的B型T细胞仅识别外源提供的肽。B型T细胞与自身免疫性疾病有关，可能通过逃避阴性选择而破坏耐受性。在这里，我们表明，沙门氏菌差异影响抗原呈递给A型和B T细胞。用鼠伤寒沙门氏菌感染骨髓来源的树突状细胞（BMDC）。Typhimurium）减少抗原向A型T细胞的呈递，但增强外源肽向B型T细胞的呈递。暴露于S。鼠伤寒沙门氏菌足以增强B型T细胞活化。鼠伤寒沙门氏菌感染减少表面表达的MHC-II，通过不变的链独立的运输机制，导致积累的MHC-II在多囊泡体。降低S. Typhimurium感染的BMDC与A型T细胞抗原呈递减少相关。沙门氏菌感染与反应性关节炎有关。因此，沙门氏菌抗原呈递向B型反应的极化可能是自身免疫性疾病如反应性关节炎的诱发因素。
Distinct peptide-MHC-II complexes, recognised by Type A and B CD4+ T-cell subsets, are generated when antigen is loaded in different intracellular compartments. Conventional Type A T cells recognize their peptide epitope regardless of the route of processing, whereas unconventional Type B T cells only recognise exogenously supplied peptide. Type B T cells are implicated in autoimmune conditions and may break tolerance by escaping negative selection. Here we show that Salmonella differentially influences presentation of antigen to Type A and B T cells. Infection of bone marrow-derived dendritic cells (BMDCs) with Salmonella enterica serovar Typhimurium (S. Typhimurium) reduced presentation of antigen to Type A T cells but enhanced presentation of exogenous peptide to Type B T cells. Exposure to S. Typhimurium was sufficient to enhance Type B T-cell activation. Salmonella Typhimurium infection reduced surface expression of MHC-II, by an invariant chain-independent trafficking mechanism, resulting in accumulation of MHC-II in multi-vesicular bodies. Reduced MHC-II surface expression in S. Typhimurium-infected BMDCs correlated with reduced antigen presentation to Type A T cells. Salmonella infection is implicated in reactive arthritis. Therefore, polarisation of antigen presentation towards a Type B response by Salmonella may be a predisposing factor in autoimmune conditions such as reactive arthritis.
登录
查看更多内容
DOI：
10.1073/pnas.0502206102
发表时间：
2005-05-31
影响因子：
11.1
作者：
McCormick, PJ;Martina, JA;Bonifacino, JS
通讯作者：
Bonifacino, JS
影响因子：
64.5
作者：
BAKKE, O;DOBBERSTEIN, B
通讯作者：
DOBBERSTEIN, B
影响因子：
32.4
作者：
McSorley, SJ;Asch, S;Jenkins, MK
通讯作者：
Jenkins, MK
影响因子：
4.4
作者：
Cheminay, C;Möhlenbrink, A;Hensel, M
通讯作者：
Hensel, M
DOI：
10.1073/pnas.0906735106
发表时间：
2009-08-18
影响因子：
11.1
作者：
Lapaque, Nicolas;Hutchinson, James L.;Kelly, Adrian P.
通讯作者：
Kelly, Adrian P.