Intra-arterial chemotherapy targeting metastatic cervical lymph nodes in head and neck cancer
Intra-arterial chemotherapy targeting metastatic cervical lymph nodes in head and neck cancer
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针对头颈癌转移性颈部淋巴结的动脉内化疗
DOI：
10.1080/00016489.2021.2003858
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发表时间：
2021
影响因子：
1.4
通讯作者：
Yoshizaki Tomokazu
中科院分区：
文献类型：
--
作者：
Murono Shigeyuki;Komori Takeshi;Endo Kazuhira;Kondo Satoru;Wakisaka Naohiro;Yoshizaki Tomokazu
背景大型颈部淋巴结和转移性淋巴结向结外延伸被认为是头颈部鳞状细胞癌 (HNC) 的不良预后因素。目的/目标检查针对 HNC 淋巴结 (LN) 的动脉内化疗 (iaCT) 的疗效。材料和方法我们对 41 例喉癌和下咽癌患者进行回顾性分析，显示转移性颈部 LN 大于20 mm采用iaCT联合放疗进行治疗。将顺铂注入 LN 分为三组：不给药（NO）、通过与原发肿瘤供血相同的动脉（SAME）和通过与原发肿瘤供血不同的动脉（DIFFERENT）。结果尽管 DIFFERENT 组的 LN 平均大小大于其他组，但与 NO 组相比，观察到 DIFFERENT 组有更有利的三年区域控制趋势。当通过 CT 血管造影观察到淋巴结整体强化而非部分强化时，“DIFFERENT”（p< .05）和“DIFFERENT + SAME”（p< .05）均获得了更好的区域控制。结外延伸可能是预测不利区域控制的一个因素。结论/意义当淋巴结相对较大的 HNC 计划进行 iaCT 时，靶向淋巴结可能有助于避免颈清扫术。
BackgroundLarge cervical lymph nodes and the extranodal extension of metastatic lymph nodes are considered poor prognostic factors in head and neck squamous cell carcinoma (HNC).Aims/objectivesThe efficacy of intra-arterial chemotherapy (iaCT) targeting lymph node (LN) in HNC was examined.Materials and methodsWe performed a retrospective review of 41 patients with laryngeal and hypopharyngeal cancer showing metastatic cervical LN larger than 20 mm treated with iaCT with concurrent radiotherapy. The administration of cisplatin into LN was divided into three groups: no administration (NO),viathe same artery as that supplying the primary tumor (SAME), andviaa different artery from that supplying the primary tumor (DIFFERENT).ResultsA trend toward a more favorable three-year regional control in DIFFERENT compared to NO was observed, although the mean size of LN in DIFFERENT was larger than in the other groups. A better regional control was obtained in both DIFFERENT (p< .05) and DIFFERENT + SAME (p< .05) when overall rather than partial enhancement of lymph node by CT angiography was observed. Extranodal extension could be a factor predicting unfavorable regional control.Conclusions/significanceTargeting lymph node may be helpful to avoid neck dissection when iaCT was planned in HNC with relatively large LNs.
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头颈部鳞状细胞癌根治性放射治疗后计划的颈清扫术
DOI：
10.1002/hed.10187
发表时间：
2002
期刊：
Head & Neck
影响因子：
--
作者：
W. Mendenhall;D. Villaret;R. Amdur;R. Hinerman;A. Mancuso
通讯作者：
A. Mancuso
上呼吸道和消化道癌颈部淋巴结转移的预后因素：15年期间1,713例的研究
DOI：
10.1288/00005537-198701000-00019
发表时间：
1987
期刊：
The Laryngoscope
影响因子：
--
作者：
J. Richard;D. Saravane;Y. Cachin;H. Sancho;C. Micheau
通讯作者：
C. Micheau
影响因子：
158.5
作者：
Forastiere, AA;Goepfert, H;Cooper, J
通讯作者：
Cooper, J
晚期头颈癌放化疗后计划进行颈清扫术：对所有人都有必要吗？
DOI：
--
发表时间：
2006
期刊：
Head and Neck
影响因子：
--
作者：
P. Pellitteri;A. Ferlito;A. Rinaldo;J. Shah;R. Weber;J. Lowry;J. Medina;C. Gourin;K. Robbins;C. Suárez;A. Shaha;E. Genden;C. R. Leemans;J. Lefebvre;Luiz P. Kowalski;W. Wei
通讯作者：
W. Wei
针对晚期头颈癌的靶向超剂量顺铂放化疗方案。
影响因子：
3
作者：
K. Robbins;D. Vicario;S. Seagren;R. Weisman;P. Pellitteri;C. Kerber;L. Orloff;G. Los;S. Howell
通讯作者：
S. Howell