Kidney implications of SARS-CoV2 infection in children.
Kidney implications of SARS-CoV2 infection in children.
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DOI：
10.1007/s00467-021-05249-8
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发表时间：
2022-07
期刊：
影响因子：
--
通讯作者：
Feig DI
中科院分区：
文献类型：
--
作者：
Bjornstad EC;Seifert ME;Sanderson K;Feig DI
研究表明，严重急性呼吸综合征冠状病毒2(SARS-CoV2)感染可影响每个器官，影响范围从无症状到严重疾病。自2019年12月首次发现以来，我们对其对肾脏疾病的影响的了解有所增加。一般来说，儿童的疾病没有成人严重，这一趋势似乎延伸到特殊的儿科肾脏人群(例如，慢性肾脏疾病和免疫抑制的实体器官移植患者或肾病综合征患者)。然而，在一小部分感染SARS-CoV2的儿童中，SARS-CoV2会导致一系列的肾脏表现，从急性肾脏损伤到血栓性微血管病变，可能会增加发病率和死亡率。在接受肾脏替代治疗的SARS-CoV2感染的儿童中，其他的考虑因素是体外电路凝结的倾向。这篇综述为儿科肾病专家提供了我们目前对SARS-CoV2的最新了解，并强调了在这一持续的大流行期间未来研究需要解决的知识差距，特别是在此期间扩大的社会差距。
Research indicates that severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection can impact every organ, and the effects can range from asymptomatic to severe disease. Since it was first discovered in December 2019, our understanding has grown about its impact on kidney disease. In general, children have less severe disease than adults, and this tendency appears to extend to special pediatric kidney populations (e.g., chronic kidney disease and immunosuppressed patients with solid organ transplants or nephrotic syndrome). However, in a fraction of infected children, SARS-CoV2 causes an array of kidney manifestations, ranging from acute kidney injury to thrombotic microangiopathy, with potential implications for increased risk of morbidity and mortality. Additional considerations surround the propensity for clotting extracorporeal circuits in children with SARS-CoV2 infection that are receiving kidney replacement therapy. This review provides an update on our current understanding of SARS-CoV2 for pediatric nephrologists and highlights knowledge gaps to be addressed by future research during this ongoing pandemic, particularly the social disparities magnified during this period.
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