Detection of SARS-CoV-2 antibodies in pediatric kidney transplant patients.
Detection of SARS-CoV-2 antibodies in pediatric kidney transplant patients.
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DOI：
10.1186/s12882-021-02325-x
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发表时间：
2021-04-07
期刊：
影响因子：
2.3
通讯作者：
Al-Quhaidan N
中科院分区：
文献类型：
--
作者：
Alshami A;Al Attas R;Azzam A;Mohammed A;Al-Quhaidan N
在免疫功能正常的儿童中研究了SARS-CoV-2感染的血清阳性率。然而，儿童肾移植人群（PKT）的数据缺乏。我们使用两种商业免疫测定法（测量针对SARS-CoV-2刺突蛋白的IgG抗体和针对核衣壳(N)蛋白的IgG抗体）筛选了72名参加门诊常规血液检查的PKT受者。大多数血清学阳性的患者在随后的临床随访中至少进行了一次额外的血清学检测。如果患者两次检测呈阳性，则确诊为SARS-CoV-2感染。72例筛查患者中有8例（11.1%）在两项血清学检测中均呈SARS-CoV-2 IgG抗体阳性。在检测呈阳性的人中，有4人在筛查前的SARS-CoV-2 PCR结果呈阳性。所有患者均无症状或有轻度症状史。在中位随访75天（IQR, 44.5, 86.5天）时，所有检测患者抗体持续呈阳性。1例患者在感染后75天PCR检测阳性，120天血清学检测阳性。我们人群中SARS-CoV-2的血清阳性率相对较高（11.1%）。尽管所有患者均无症状或轻度症状，但尽管服用三联免疫抑制剂，他们仍表现出强烈的体液免疫反应，并持续数月。这些发现对这一群体的疫苗接种效果具有积极意义。
The seroprevalence of SARS-CoV-2 infection has been studied in immunocompetent children. However, data in the pediatric kidney transplant population (PKT) are lacking. Using two commercial immunoassays that measured IgG antibodies against SARS-CoV-2 spike protein and IgG against the nucleocapsid (N) protein, we screened 72 PKT recipients who attended the outpatient clinic for routine blood work. The majority of patients with positive serology underwent an additional serology test at least once during subsequent clinical follow-up. Patients were confirmed to have SARS-CoV-2 infection if they had two positive tests. Eight patients out of the 72 screened (11.1%) had positive results for SARS-CoV-2 IgG antibodies in both serological tests. Of those who tested positive, 4 had positive SARS-CoV-2 PCR results before screening. All patients were asymptomatic or had a history of mild symptoms. All tested patients had persistently positive antibodies at a median follow-up time of 75 days (IQR, 44.5, 86.5 days). One patient had a positive PCR test at 75 days and a positive serology test at 120 days post infection. The seroprevalence of SARS-CoV-2 was relatively high (11.1%) in our population. Although all patients were asymptomatic or mildly symptomatic, they mounted a strong humoral immune response that persisted for a few months despite being on triple immunosuppressants. These findings have positive implications regarding vaccination efficacy in this group.
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