How to reprogram human fibroblasts to neurons.
How to reprogram human fibroblasts to neurons.
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DOI：
10.1186/s13578-020-00476-2
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发表时间：
2020
影响因子：
7.5
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Xu Z;Su S;Zhou S;Yang W;Deng X;Sun Y;Li L;Li Y
神经元的破坏和死亡可导致神经退行性疾病。治疗神经退行性疾病和神经系统损伤的一种可能的方法是通过细胞移植替换受损和死亡的神经元。如果新的神经元能够替代丢失的神经元，患者就有可能重新获得失去的记忆、运动等功能，因此，方便、高效地获取神经元对于治疗神经系统疾病至关重要。近年来，将人成纤维细胞重编程为神经元的研究层出不穷，本文对这些研究进行了综述。科学家发现小分子和转录因子在重编程和诱导神经元产生中起着至关重要的作用。同时，体内生理微环境和体外理化因素对神经元的诱导起着至关重要的作用。因此，本文对这些相关因素进行了总结和分析。此外，由于物理因子在将人成纤维细胞重编程为神经元的过程中具有安全、微创等独特优势，因此具有更广阔的应用前景。因此，本文还总结了一些成功的利用成纤维细胞获得神经元的物理机制，这将为体细胞重编程提供新的思路。
Destruction and death of neurons can lead to neurodegenerative diseases. One possible way to treat neurodegenerative diseases and damage of the nervous system is replacing damaged and dead neurons by cell transplantation. If new neurons can replace the lost neurons, patients may be able to regain the lost functions of memory, motor, and so on. Therefore, acquiring neurons conveniently and efficiently is vital to treat neurological diseases. In recent years, studies on reprogramming human fibroblasts into neurons have emerged one after another, and this paper summarizes all these studies. Scientists find small molecules and transcription factors playing a crucial role in reprogramming and inducing neuron production. At the same time, both the physiological microenvironment in vivo and the physical and chemical factors in vitro play an essential role in the induction of neurons. Therefore, this paper summarized and analyzed these relevant factors. In addition, due to the unique advantages of physical factors in the process of reprogramming human fibroblasts into neurons, such as safe and minimally invasive, it has a more promising application prospect. Therefore, this paper also summarizes some successful physical mechanisms of utilizing fibroblasts to acquire neurons, which will provide new ideas for somatic cell reprogramming.
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影响因子：
25
作者：
Blanchard, Joel W.;Eade, Kevin T.;Szucs, Attila;Lo Sardo, Valentina;Tsunemoto, Rachel K.;Williams, Daniel;Sanna, Pietro Paolo;Baldwin, Kristin K.
通讯作者：
Baldwin, Kristin K.
体细胞直接转化为诱导神经元
影响因子：
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作者：
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作者：
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Yoo AS
影响因子：
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作者：
Hu, Weiwei;Feng, Zehua;Feng, Meijiang
通讯作者：
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影响因子：
23.9
作者：
Han, Dong Wook;Tapia, Natalia;Schoeler, Hans R.
通讯作者：
Schoeler, Hans R.