Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia.
Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia.
复制标题
微生物衍生代谢物是年龄相关认知能力下降和痴呆的危险因素。
DOI：
10.1186/s13024-022-00548-6
复制
发表时间：
2022-06-17
影响因子：
15.1
通讯作者：
Vauzour, David
中科院分区：
文献类型：
--
作者：
Connell, Emily;Le Gall, Gwenaelle;Pontifex, Matthew G.;Sami, Saber;Cryan, John F.;Clarke, Gerard;Mueller, Michael;Vauzour, David
全球人口逐渐老龄化的一个后果是，世界范围内与年龄有关的认知能力下降和痴呆症日益普遍。在缺乏有效的治疗干预措施的情况下，识别与认知能力下降相关的风险因素变得越来越重要。新颖的观点表明，肠道、其微生物组和中枢神经系统之间的动态双向通讯系统（通常称为微生物组-肠道-脑轴）可能是认知健康和疾病的一个促成因素。然而，确切的机制仍不明确。肠道中产生的微生物衍生代谢物可以穿过肠上皮屏障，进入体循环并触发直接和间接影响中枢神经系统及其功能的生理反应。该系统的失调（即，生态失调）可以调节细胞毒性代谢物的产生，促进神经炎症并对认知产生负面影响。在这篇综述中，我们探讨了微生物衍生的代谢产物（次级胆汁酸，三甲基胺-N-氧化物（TMAO），色氨酸衍生物等）及其对认知功能和神经退行性疾病的影响之间的关键联系，特别关注其作为认知能力下降的风险因素的作用。
A consequence of our progressively ageing global population is the increasing prevalence of worldwide age-related cognitive decline and dementia. In the absence of effective therapeutic interventions, identifying risk factors associated with cognitive decline becomes increasingly vital. Novel perspectives suggest that a dynamic bidirectional communication system between the gut, its microbiome, and the central nervous system, commonly referred to as the microbiota-gut-brain axis, may be a contributing factor for cognitive health and disease. However, the exact mechanisms remain undefined. Microbial-derived metabolites produced in the gut can cross the intestinal epithelial barrier, enter systemic circulation and trigger physiological responses both directly and indirectly affecting the central nervous system and its functions. Dysregulation of this system (i.e., dysbiosis) can modulate cytotoxic metabolite production, promote neuroinflammation and negatively impact cognition. In this review, we explore critical connections between microbial-derived metabolites (secondary bile acids, trimethylamine-N-oxide (TMAO), tryptophan derivatives and others) and their influence upon cognitive function and neurodegenerative disorders, with a particular interest in their less-explored role as risk factors of cognitive decline.
登录
查看更多内容
与奖励相关行为中的多巴胺信号传导。
影响因子：
3.5
作者：
Baik JH
通讯作者：
Baik JH
影响因子：
4.2
作者：
Alexander GE;Bergfield KL;Chen K;Reiman EM;Hanson KD;Lin L;Bandy D;Caselli RJ;Moeller JR
通讯作者：
Moeller JR
影响因子：
4.2
作者：
Adluru, Nagesh;Destiche, Daniel J.;Bendlin, Barbara B.
通讯作者：
Bendlin, Barbara B.
DOI：
10.1016/j.xcrm.2020.100138
发表时间：
2020-11-17
期刊：
Cell reports. Medicine
影响因子：
--
作者：
Baloni P;Funk CC;Yan J;Yurkovich JT;Kueider-Paisley A;Nho K;Heinken A;Jia W;Mahmoudiandehkordi S;Louie G;Saykin AJ;Arnold M;Kastenmüller G;Griffiths WJ;Thiele I;Alzheimer’s Disease Metabolomics Consortium;Kaddurah-Daouk R;Price ND
通讯作者：
Price ND
DOI：
10.1152/ajpgi.00190.2011
发表时间：
2012-01-01
影响因子：
4.5
作者：
Bajaj, Jasmohan S.;Ridlon, Jason M.;Gillevet, Patrick M.
通讯作者：
Gillevet, Patrick M.