How cells channel their stress: Interplay between Piezo1 and the cytoskeleton.
How cells channel their stress: Interplay between Piezo1 and the cytoskeleton.
复制标题
细胞如何引导其应力：压电1和细胞骨架之间的相互作用。
DOI：
10.1016/j.semcdb.2017.06.018
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发表时间：
2017-11
影响因子：
7.3
通讯作者：
Pathak MM
中科院分区：
文献类型：
--
作者：
Nourse JL;Pathak MM
细胞在其环境中不断遇到机械刺激，例如动态力和细胞外基质的机械特征。这些机械信号被转换成生化信号，并与遗传和化学信号相结合，以调节各种生理过程。细胞还积极地产生力量来内部运输货物，探索其环境的物理特性，并在发育过程中定位自己和其他细胞。因此，机械力对发育、稳态和修复至关重要。细胞利用几种分子和生物物理策略来检测和产生机械力。在这里，我们讨论了一类重要的分子参与传感和转导机械力-机械激活离子通道。我们主要关注Piezo 1离子通道，并研究其与细胞骨架的关系。
Cells constantly encounter mechanical stimuli in their environment, such as dynamic forces and mechanical features of the extracellular matrix. These mechanical cues are transduced into biochemical signals, and integrated with genetic and chemical signals to modulate diverse physiological processes. Cells also actively generate forces to internally transport cargo, to explore the physical properties of their environment and to spatially position themselves and other cells during development. Mechanical forces are therefore central to development, homeostasis, and repair. Several molecular and biophysical strategies are utilized by cells for detecting and generating mechanical forces. Here we discuss an important class of molecules involved in sensing and transducing mechanical forces – mechanically-activated ion channels. We focus primarily on the Piezo1 ion channel, and examine its relationship with the cellular cytoskeleton.
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影响因子：
16.6
作者：
Cox CD;Bae C;Ziegler L;Hartley S;Nikolova-Krstevski V;Rohde PR;Ng CA;Sachs F;Gottlieb PA;Martinac B
通讯作者：
Martinac B
DOI：
10.1111/nyas.12874
发表时间：
2015-01-01
期刊：
ANNALS REPORTS, VOL 1352
影响因子：
--
作者：
Brohawn, Stephen G.
通讯作者：
Brohawn, Stephen G.
DOI：
10.1073/pnas.1412740111
发表时间：
2014-11-11
影响因子：
11.1
作者：
Blumenthal, Nils R.;Hermanson, Ola;Shastri, V. Prasad
通讯作者：
Shastri, V. Prasad
影响因子：
4.8
作者：
Cortesio, Christa L.;Boateng, Lindsy R.;Huttenlocher, Anna
通讯作者：
Huttenlocher, Anna
影响因子：
64.8
作者：
Gudipaty SA;Lindblom J;Loftus PD;Redd MJ;Edes K;Davey CF;Krishnegowda V;Rosenblatt J
通讯作者：
Rosenblatt J