Ectopic transplantation of the accessory medulla restores circadian locomotor rhythms in arrhythmic cockroaches (Leucophaea maderae)
Ectopic transplantation of the accessory medulla restores circadian locomotor rhythms in arrhythmic cockroaches (Leucophaea maderae)
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辅助髓质异位移植可恢复心律失常蟑螂（Leucophaea maderae）的昼夜节律
DOI：
--
复制
发表时间：
2003
影响因子：
2.8
通讯作者：
M. Stengl
中科院分区：
文献类型：
--
作者：
Thomas Reischig;M. Stengl
摘要 动物大脑中存在内源性生物钟首先在蟑螂 Leucophaea maderae 中得到证实。然而，时钟的细胞基础仍然难以捉摸，直到色素分散激素免疫反应性神经元（在果蝇中表达周期和永恒的时钟基因）被提议作为起搏器候选者。在一些昆虫物种中，色素分散激素免疫反应性神经元与附属髓质（视叶中的一个小神经纤维）密切相关，被认为是生物钟神经纤维。在这里，我们证明将成年副髓质异位移植到无视叶蟑螂中可以恢复马德拉蟑螂的昼夜运动活动节律。所有经过组织学检查的恢复昼夜节律活动的蟑螂都从移植物到原大脑的原始目标处再生了色素分散激素免疫反应性纤维。数据表明，辅助髓质是控制蟑螂运动活动节律的昼夜节律起搏器。色素分散激素免疫反应神经元是否是控制运动活动节律的唯一昼夜节律起搏细胞仍有待检验。
SUMMARY The presence of an endogenous circadian clock in the brain of an animal was first demonstrated in the cockroach Leucophaea maderae. However, the clock's cellular basis remained elusive until pigment-dispersing hormone-immunoreactive neurons, which express the clock genes period and timeless in Drosophila, were proposed as pacemaker candidates. In several insect species, pigment-dispersing hormone-immunoreactive neurons are closely associated with the accessory medulla, a small neuropil in the optic lobe, which was suggested to be a circadian clock neuropil. Here, we demonstrate that ectopic transplantation of adult accessory medulla into optic lobe-less cockroaches restores circadian locomotor activity rhythms in L. maderae. All histologically examined cockroaches that regained circadian activity regenerated pigment-dispersing hormone-immunoreactive fibres from the grafts to original targets in the protocerebrum. The data show that the accessory medulla is the circadian pacemaker controlling locomotor activity rhythms in the cockroach. Whether pigment-dispersing hormone-immunoreactive neurons are the only circadian pacemaker cells controlling locomotor activity rhythms remains to be examined.
供体年龄影响视交叉上核移植物恢复昼夜节律的能力。
DOI：
10.1016/0165-3806(93)90103-h
发表时间：
1993
期刊：
Brain research. Developmental brain research
影响因子：
--
作者：
Romero,MT;Lehman,MN;Silver,R
通讯作者：
Silver,R
影响因子：
56.9
作者：
RALPH, MR;FOSTER, RG;MENAKER, M
通讯作者：
MENAKER, M