Non-Targeted Metabolomics Approach Revealed Significant Changes in Metabolic Pathways in Patients with Chronic Traumatic Encephalopathy.
Non-Targeted Metabolomics Approach Revealed Significant Changes in Metabolic Pathways in Patients with Chronic Traumatic Encephalopathy.
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非靶向代谢组学方法揭示了慢性创伤性脑病患者代谢途径的显著变化。
DOI：
10.3390/biomedicines10071718
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发表时间：
2022-07-15
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
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作者：
慢性创伤性脑病（CTE）是一种神经退行性疾病，常见于运动员和那些经历过重复性头部创伤的人。CTE与多种神经病变相关，导致CTE患者认知和行为障碍。然而，目前CTE只能在死亡后通过脑部尸检进行诊断，很难与其他具有相似临床特征的神经退行性疾病区分开来。为了更好地了解这种多面性疾病，并确定CTE患者和对照组死后脑组织的代谢差异，我们进行了基于超高效液相色谱-质谱（UPLC-MS）的非靶向代谢组学。通过多因素和通路分析，我们发现CTE患者大脑中参与星形胶质细胞活化、苯丙氨酸和酪氨酸代谢的代谢物发生了显著变化。本研究中发现的CTE的独特代谢特征与认知功能障碍、淀粉样蛋白沉积和神经炎症有关。总之，这项研究为CTE的发病机制提供了新的见解，并为该疾病的诊断和治疗提供了有吸引力的靶点。
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that is frequently found in athletes and those who have experienced repetitive head traumas. CTE is associated with a variety of neuropathologies, which cause cognitive and behavioral impairments in CTE patients. However, currently, CTE can only be diagnosed after death via brain autopsy, and it is challenging to distinguish it from other neurodegenerative diseases with similar clinical features. To better understand this multifaceted disease and identify metabolic differences in the postmortem brain tissues of CTE patients and control subjects, we performed ultra-high performance liquid chromatography–mass spectrometry (UPLC-MS)-based non-targeted metabolomics. Through multivariate and pathway analysis, we found that the brains of CTE patients had significant changes in the metabolites involved in astrocyte activation, phenylalanine, and tyrosine metabolism. The unique metabolic characteristics of CTE identified in this study were associated with cognitive dysfunction, amyloid-beta deposition, and neuroinflammation. Altogether, this study provided new insights into the pathogenesis of CTE and suggested appealing targets for both diagnosis and treatment for the disease.
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影响因子：
3.2
作者：
Bieniek KF;Cairns NJ;Crary JF;Dickson DW;Folkerth RD;Keene CD;Litvan I;Perl DP;Stein TD;Vonsattel JP;Stewart W;Dams-O'Connor K;Gordon WA;Tripodis Y;Alvarez VE;Mez J;Alosco ML;McKee AC;TBI/CTE Research Group
通讯作者：
TBI/CTE Research Group
DOI：
10.1186/s13195-021-00872-x
发表时间：
2021-08-12
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Alosco ML;Mariani ML;Adler CH;Balcer LJ;Bernick C;Au R;Banks SJ;Barr WB;Bouix S;Cantu RC;Coleman MJ;Dodick DW;Farrer LA;Geda YE;Katz DI;Koerte IK;Kowall NW;Lin AP;Marcus DS;Marek KL;McClean MD;McKee AC;Mez J;Palmisano JN;Peskind ER;Tripodis Y;Turner RW 2nd;Wethe JV;Cummings JL;Reiman EM;Shenton ME;Stern RA;DIAGNOSE CTE Research Project Investigators
通讯作者：
DIAGNOSE CTE Research Project Investigators
影响因子：
9.9
作者：
Levine, B.;Kovacevic, N.;Black, S. E.
通讯作者：
Black, S. E.
钙离子通过激活微粒体前列腺素 E 合酶 1 刺激 Tau 过度磷酸化
影响因子：
4.8
作者：
Cao, Long-Long;Guan, Pei-Pei;Wang, Pu
通讯作者：
Wang, Pu
影响因子：
2.4
作者：
Kim, Yoon Hwan;Shim, Hyun Soo;Lee, Jeongae
通讯作者：
Lee, Jeongae