Developing methods to detect and diagnose chronic traumatic encephalopathy during life: rationale, design, and methodology for the DIAGNOSE CTE Research Project.
Developing methods to detect and diagnose chronic traumatic encephalopathy during life: rationale, design, and methodology for the DIAGNOSE CTE Research Project.
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DOI：
10.1186/s13195-021-00872-x
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发表时间：
2021-08-12
期刊：
影响因子：
--
通讯作者：
DIAGNOSE CTE Research Project Investigators
中科院分区：
文献类型：
--
作者：
Alosco ML;Mariani ML;Adler CH;Balcer LJ;Bernick C;Au R;Banks SJ;Barr WB;Bouix S;Cantu RC;Coleman MJ;Dodick DW;Farrer LA;Geda YE;Katz DI;Koerte IK;Kowall NW;Lin AP;Marcus DS;Marek KL;McClean MD;McKee AC;Mez J;Palmisano JN;Peskind ER;Tripodis Y;Turner RW 2nd;Wethe JV;Cummings JL;Reiman EM;Shenton ME;Stern RA;DIAGNOSE CTE Research Project Investigators
慢性创伤性脑病（CTE）是一种神经退行性疾病，已被神经病理学诊断为暴露于反复头部撞击的脑供体，包括拳击手和美式橄榄球、足球、冰球和橄榄球运动员。CTE还不能在生前诊断出来。2015年12月，国家神经疾病和中风研究所授予了一项为期7年的拨款（U01NS093334），用于资助“慢性创伤性脑病（诊断CTE）研究项目的客观研究和评估的诊断、成像和遗传学网络”。这个多中心项目的目标是：开发CTE的体内液体和神经成像生物标志物；描述其临床表现；完善和验证临床研究诊断标准（即创伤性脑病综合征[TES]）；检查重复头部撞击暴露、遗传和其他危险因素；并为研究界提供匿名数据和生物样本的共享资源。在本文中，我们提供了诊断CTE研究项目的基本原理，设计和方法的详细概述。目标样本和样本量为240名男性参与者，年龄为45-74岁，其中包括120名前职业足球运动员，60名前大学足球运动员，以及60名无头部创伤史或参加有组织的接触性运动的无症状参与者。参与者在美国四个地点之一进行评估，并接受以下基线程序：神经学和神经心理学检查；Tau和淀粉样正电子发射断层扫描；磁共振成像与光谱学；腰椎穿刺;采集血液和唾液；以及神经精神、认知和日常功能的标准化自我报告测量。研究伙伴完成了类似的信息报告措施。随访评估将在基线后3年进行。召开多学科诊断共识会议，并检查TES诊断标准的可靠性和有效性。参与者登记和所有基线评估于2020年2月完成。2019年10月开始进行为期三年的后续评估。然而，当面评估随着COVID-19大流行而停止，并于2021年2月恢复为远程4年随访评估（包括基于电话、在线和视频会议的认知、神经精神和神经学检查，以及在家抽血）。诊断CTE研究项目的研究成果应有助于在生命中发现和诊断CTE，从而加快对CTE的危险因素、机制、流行病学、治疗和预防的研究。NCT02798185在线版本包含补充材料，可在10.1186/s13195-021-00872-x获得。
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that has been neuropathologically diagnosed in brain donors exposed to repetitive head impacts, including boxers and American football, soccer, ice hockey, and rugby players. CTE cannot yet be diagnosed during life. In December 2015, the National Institute of Neurological Disorders and Stroke awarded a seven-year grant (U01NS093334) to fund the “Diagnostics, Imaging, and Genetics Network for the Objective Study and Evaluation of Chronic Traumatic Encephalopathy (DIAGNOSE CTE) Research Project.” The objectives of this multicenter project are to: develop in vivo fluid and neuroimaging biomarkers for CTE; characterize its clinical presentation; refine and validate clinical research diagnostic criteria (i.e., traumatic encephalopathy syndrome [TES]); examine repetitive head impact exposure, genetic, and other risk factors; and provide shared resources of anonymized data and biological samples to the research community. In this paper, we provide a detailed overview of the rationale, design, and methods for the DIAGNOSE CTE Research Project. The targeted sample and sample size was 240 male participants, ages 45–74, including 120 former professional football players, 60 former collegiate football players, and 60 asymptomatic participants without a history of head trauma or participation in organized contact sports. Participants were evaluated at one of four U.S. sites and underwent the following baseline procedures: neurological and neuropsychological examinations; tau and amyloid positron emission tomography; magnetic resonance imaging and spectroscopy; lumbar puncture; blood and saliva collection; and standardized self-report measures of neuropsychiatric, cognitive, and daily functioning. Study partners completed similar informant-report measures. Follow-up evaluations were intended to be in-person and at 3 years post-baseline. Multidisciplinary diagnostic consensus conferences are held, and the reliability and validity of TES diagnostic criteria are examined. Participant enrollment and all baseline evaluations were completed in February 2020. Three-year follow-up evaluations began in October 2019. However, in-person evaluation ceased with the COVID-19 pandemic, and resumed as remote, 4-year follow-up evaluations (including telephone-, online-, and videoconference-based cognitive, neuropsychiatric, and neurologic examinations, as well as in-home blood draw) in February 2021. Findings from the DIAGNOSE CTE Research Project should facilitate detection and diagnosis of CTE during life, and thereby accelerate research on risk factors, mechanisms, epidemiology, treatment, and prevention of CTE. NCT02798185 The online version contains supplementary material available at 10.1186/s13195-021-00872-x.
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DOI：
10.1016/j.jalz.2018.05.004
发表时间：
2018-09
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Alosco ML;Tripodis Y;Fritts NG;Heslegrave A;Baugh CM;Conneely S;Mariani M;Martin BM;Frank S;Mez J;Stein TD;Cantu RC;McKee AC;Shaw LM;Trojanowski JQ;Blennow K;Zetterberg H;Stern RA
通讯作者：
Stern RA
影响因子：
11.2
作者：
Alosco ML;Mez J;Tripodis Y;Kiernan PT;Abdolmohammadi B;Murphy L;Kowall NW;Stein TD;Huber BR;Goldstein LE;Cantu RC;Katz DI;Chaisson CE;Martin B;Solomon TM;McClean MD;Daneshvar DH;Nowinski CJ;Stern RA;McKee AC
通讯作者：
McKee AC
影响因子：
2.7
作者：
Adler, Caleb M.;DelBello, Melissa P.;Divine, Jon
通讯作者：
Divine, Jon
影响因子：
6.8
作者：
Alosco ML;Kasimis AB;Stamm JM;Chua AS;Baugh CM;Daneshvar DH;Robbins CA;Mariani M;Hayden J;Conneely S;Au R;Torres A;McClean MD;McKee AC;Cantu RC;Mez J;Nowinski CJ;Martin BM;Chaisson CE;Tripodis Y;Stern RA
通讯作者：
Stern RA
DOI：
10.1002/alz.12176
发表时间：
2021-01
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Avila JF;Rentería MA;Jones RN;Vonk JMJ;Turney I;Sol K;Seblova D;Arias F;Hill-Jarrett T;Levy SA;Meyer O;Racine AM;Tom SE;Melrose RJ;Deters K;Medina LD;Carrión CI;Díaz-Santos M;Byrd DR;Chesebro A;Colon J;Igwe KC;Maas B;Brickman AM;Schupf N;Mayeux R;Manly JJ
通讯作者：
Manly JJ