Alterations in patients with major depressive disorder before and after electroconvulsive therapy measured by fractional amplitude of low-frequency fluctuations (fALFF).
Alterations in patients with major depressive disorder before and after electroconvulsive therapy measured by fractional amplitude of low-frequency fluctuations (fALFF).
复制标题
通过低频波动（FALFF）测量的电抽搐治疗前后，重度抑郁症患者的改变（FALFF）。
DOI：
10.1016/j.jad.2018.10.099
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发表时间：
2019-02-01
影响因子：
6.6
通讯作者：
Sun M
中科院分区：
文献类型：
--
作者：
Qiu H;Li X;Luo Q;Li Y;Zhou X;Cao H;Zhong Y;Sun M
电休克治疗（ECT）是重度抑郁症（MDD）患者的一种重要治疗选择。然而，ECT在MDD中的作用机制尚不清楚。24例重度MDD患者和14例健康对照者入组本研究。对MDD患者进行了8次ECT治疗，使用双颞位置的双脉冲方波信号。采用静息态功能磁共振成像（rs-fMRI）研究抑郁症患者ECT治疗前后局部脑血流的变化。随后，我们采用低频波动分数振幅（fALFF）来评估局部脑活动的变化。与健康对照组相比，MDD患者ECT前（pre-ECT）小脑叶、海马旁回、梭状回、扣带回前部和丘脑的fALFF显著增加。在另一项比较中，ECT前患者小脑前叶、梭状回、海马回、额中回和额下回的fALFF显著大于ECT后的fALFF。只有两个rs-fMRI扫描进行了预定义的时间：第一次和第八次ECT治疗后。在ECT会话期间进行更多扫描将产生更多信息。此外，本研究的样本量有限。对照组的人数相对较少。更多的受试者将产生更有力的结果。健康对照组和ECT治疗后患者小脑前叶、梭状回和海马旁回的fALFF均显著低于ECT治疗前患者。这一发现表明，ECT治疗对MDD患者的这些脑区有效。
Electroconvulsive therapy (ECT) is an important treatment option for patients with major depressive disorder (MDD). However, the mechanisms of ECT in MDD are still unclear. Twenty-four patients with severe MDD and 14 healthy controls were enrolled in this study. Eight ECT sessions were conducted for MDD patients using brief-pulse square-wave signal at bitemporal locations. To investigate the regional cerebral blood flow in MDD patients before and after ECT treatments by resting-state functional magnetic resonance imaging (rs-fMRI), the patients were scanned twice (before the first ECT and after the eighth ECT) for data acquisition. Afterward, we adopted fractional amplitude of low-frequency fluctuations (fALFF) to assess the alterations of regional brain activity. Compared with healthy controls, the fALFF in the cerebellum lobe, parahippocampal gyrus, fusiform gyrus, anterior cingulate gyrus, and thalamus in MDD patients before ECT (pre-ECT) was significantly increased. In another comparison, the fALFF in the cerebellum anterior lobe, fusiform gyrus, insula, parahippocampal gyrus, middle frontal gyrus, and inferior frontal gyrus in pre-ECT patients was significantly greater than the post-ECT fALFF. Only two rs-fMRI scans were conducted at predefined times: before the first and after the eighth ECT treatment. More scans during the ECT sessions would yield more information. In addition, the sample size in this study was limited. The number of control subjects was relatively small. A larger number of subjects would produce more robust findings. The fALFF of both healthy controls and post-ECT patients in cerebellum anterior lobe, fusiform gyrus, and parahippocampal gyrus is significantly lower than the fALFF of pre-ECT patients. This finding demonstrates that ECT treatment is effective on these brain areas in MDD patients.
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影响因子：
25.8
作者：
Kaiser, Roselinde H.;Andrews-Hanna, Jessica R.;Wager, Tor D.;Pizzagalli, Diego A.
通讯作者：
Pizzagalli, Diego A.
影响因子：
3.3
作者：
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作者：
Demenescu, L. R.;Renken, R.;Aleman, A.
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影响因子：
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作者：
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通讯作者：
Simmons, W. Kyle
影响因子：
10.6
作者：
Hamilton JP;Farmer M;Fogelman P;Gotlib IH
通讯作者：
Gotlib IH