rdgE: a novel retinal degeneration mutation in Drosophila melanogaster.
rdgE: a novel retinal degeneration mutation in Drosophila melanogaster.
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rdgE：果蝇中一种新的视网膜变性突变。
DOI：
10.1093/genetics/144.1.127
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发表时间：
1996
期刊：
影响因子：
3.3
通讯作者：
Hyde,DR
中科院分区：
文献类型：
--
作者：
Zars,T;Hyde,DR
We report isolating the Drosophilaretinal degeneration E(rdgE) mutation. The hypomorphicrdgE1allele causes rapid photoreceptor degeneration in light and a slower rate of degeneration when the flies are raised in constant darkness. TherdgE1flies exhibited an electrophysiological light response that decreased with age, coinciding with the degeneration. This suggests that degeneration caused the loss of the light response. We determined that theninaE(rhodopsin) mutation, but notnorpA[phospholipase C (PLC)], slowed therdgE-dependent degeneration. This was consistent with the light-enhanced degeneration, but revealed that the degeneration is independent of the PLC-mediated phototransduction cascade. Transmission electron microscopy revealed thatrdgE1photoreceptors exhibited a number of vesicular transport defects including unpacking/vesiculation of rhabdomeres, endocytosis of novel vesicles by photoreceptors, a buildup of very large multivesicular bodies, and an increased amount of rough endoplasmic reticulum. We determined that therdgEnull phenotype is a late embryonic lethality. Therefore,rdgE+is required in cells outside of the retina, quite possibly in a large number of neurons. Thus,rdgEmay define a mutational class that exhibits both light-enhanced retinal degeneration and a recessive null lethality by perturbing neuronal membrane biosynthesis and/or recycling.
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横纹粒周转和视紫红质循环：果蝇视网膜细胞的维持
DOI：
--
发表时间：
1988
期刊：
Journal of Neurocytology
影响因子：
--
作者：
W. S. Stark;R. Sapp;Donna Schilly
通讯作者：
Donna Schilly
缺乏突触的完整感光细胞的特性。
DOI：
--
发表时间：
1968
期刊：
The Journal of experimental zoology
影响因子：
--
作者：
Daniel M. Eichenbaum;Timothy H. Goldsmith
通讯作者：
Timothy H. Goldsmith
果蝇中的融合横纹肌（毛皮）：一种改变横纹肌形态和视网膜功能的眼睛突变。
影响因子：
1.9
作者：
Blake,A;Bender,LB;O'Day,PM;Lonergan,M;Venkatesh,TR
通讯作者：
Venkatesh,TR
影响因子：
16.2
作者：
LEE, YJ;SHAH, S;HYDE, DR
通讯作者：
HYDE, DR
果蝇 zeste 复合体抑制子 2 的遗传分析。
影响因子：
3.3
作者：
C.;M. Howe
通讯作者：
M. Howe