Regulation of neuronal development and function by ROS.

Regulation of neuronal development and function by ROS.
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DOI:
10.1002/1873-3468.12972
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发表时间:
2018-03
期刊:
影响因子:
3.5
通讯作者:
Landgraf M
Landgraf M
中科院分区:
生物学3区
文献类型:
--
作者:
Oswald MCW;Garnham N;Sweeney ST;Landgraf M

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长期以来,活性氧(ROS)一直被研究为神经系统老化、疾病和退化的破坏性因素。它们在正常生理条件下作为信号分子的作用还不太清楚。最近的研究提供了大量证据表明ROS调节神经元的发育和功能,从建立神经元极性到生长锥寻路;从调节连接和突触传递到调节神经元网络。了解受ROS调节的各种过程可能有助于我们了解ROS代谢和缓冲的变化如何随着年龄和疾病逐渐影响神经网络。
Reactive oxygen species (ROS) have long been studied as destructive agents in the context of nervous system ageing, disease and degeneration. Their roles as signalling molecules under normal physiological conditions is less well understood. Recent studies have provided ample evidence of ROS‐regulating neuronal development and function, from the establishment of neuronal polarity to growth cone pathfinding; from the regulation of connectivity and synaptic transmission to the tuning of neuronal networks. Appreciation of the varied processes that are subject to regulation by ROS might help us understand how changes in ROS metabolism and buffering could progressively impact on neuronal networks with age and disease.
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