Real-Time Imaging of Brain Tumor for Image-Guided Surgery.
Real-Time Imaging of Brain Tumor for Image-Guided Surgery.
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DOI：
10.1002/adhm.201800066
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发表时间：
2018-08
影响因子：
10
通讯作者：
Choi HS
中科院分区：
文献类型：
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作者：
Hu S;Kang H;Baek Y;El Fakhri G;Kuang A;Choi HS
手术切除的完成与否是影响脑肿瘤治疗预后的关键因素。这需要外科医生在手术室中识别残余肿瘤，并将肿瘤与邻近正常组织的接近程度进行边缘划分。肿瘤外科医生在切除过程中通常使用主观评估，如触诊质地或视觉组织差异来区分癌病变与正常组织，这可能导致肿瘤切除不完全或意外切除正常组织。此外，恶性脑肿瘤更难与正常脑组织区分，切除非癌组织可能会在手术后造成神经系统缺陷。为了优化脑肿瘤的切除边缘，人们开发了多种术中引导技术，如神经导航、磁共振成像、超声、拉曼光谱、光学荧光成像等。当与适当的造影剂联合使用时，光学荧光成像可以为神经外科医生提供实时图像指导，以提高切除的完整性，减少手术并发症。
The completion of surgical resection is a key prognostic factor in brain tumor treatment. This requires surgeons to identify residual tumors in theater as well as to margin the proximity of the tumor to adjacent normal tissue. Subjective assessments, such as texture palpation or visual tissue differences, are commonly used by oncology surgeons during resection to differentiate cancer lesions from normal tissue, which can potentially result in either an incomplete tumor resection, or accidental removal of normal tissue. Moreover, malignant brain tumors are even more difficult to distinguish from normal brain tissue, and resecting noncancerous tissue may create neurological defects after surgery. To optimize the resection margin in brain tumors, a variety of intraoperative guidance techniques are developed, such as neuronavigation, magnetic resonance imaging, ultrasound, Raman spectroscopy, and optical fluorescence imaging. When combined with appropriate contrast agents, optical fluorescence imaging can provide the neurosurgeon real-time image guidance to improve resection completeness and to decrease surgical complications.
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