Identification and characterization of the promoter of human ATF5 gene.
Identification and characterization of the promoter of human ATF5 gene.
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人ATF5基因启动子的鉴定和表征。
DOI：
10.1093/jb/mvq047
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发表时间：
2010-08
影响因子：
2.7
通讯作者：
yuanyan Wei, Yuqing Ge, Fengbiao Zhou, Hong Chen,
中科院分区：
文献类型：
--
作者：
yuanyan Wei, Yuqing Ge, Fengbiao Zhou, Hong Chen,
ATF5是b-ZIP转录因子ATF/CREB家族的成员，在多种肿瘤中高表达，并调节细胞分化、细胞存活和凋亡。然而，人类ATF5转录调控的机制尚未……
ATF5, a member of ATF/CREB family of b-ZIP transcription factors, is highly expressed in a wide variety of neoplasms and regulates cell differentiation, cell survival and apoptosis. However, the mechanism of human ATF5 transcriptional regulation has not been clarified. Here, we identified the transcription start site of the ATF5 gene, cloned its 5'-flanking region and identified the region -105 to +3 relative to the transcription start site as that having promoter activity. This region contained potential binding sites for several transcription factors, including EBF1, Sp1 and E2F1. EBF1 transcription factor binds to the ATF5 promoter and regulates the ATF5 transcription in an EBF-binding site independent manner. Thus, our studies not only provided molecular basis of ATF5 transcriptional regulation, but also identified ATF5 as a target gene of EBF1 transcription factor.
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DOI：
10.1073/pnas.240452197
发表时间：
2000-12-05
影响因子：
11.1
作者：
White, JH;McIllhinney, RA;Marshall, FH
通讯作者：
Marshall, FH
影响因子：
30.5
作者：
Pongubala, Jagan M. R.;Northrup, Daniel L.;Singh, Harinder
通讯作者：
Singh, Harinder
影响因子：
4.8
作者：
Zhu, XY;Jiang, JH;Gu, JX
通讯作者：
Gu, JX
影响因子：
4.6
作者：
H. Satake;Kazuo Ito;M. Takahara;Takashi Furukawa;M. Takagi;T. Ogino;T. Shinomura
通讯作者：
H. Satake;Kazuo Ito;M. Takahara;Takashi Furukawa;M. Takagi;T. Ogino;T. Shinomura
影响因子：
1.5
作者：
Nishioka, Takeshi;Miyai, Yusuke;Yasuda, Motoaki
通讯作者：
Yasuda, Motoaki