High expression of biglycan is associated with poor prognosis in patients with esophageal squamous cell carcinoma.
High expression of biglycan is associated with poor prognosis in patients with esophageal squamous cell carcinoma.
复制标题
双糖链蛋白聚糖的高表达与食管鳞状细胞癌患者的不良预后相关。
DOI：
--
复制
发表时间：
2013-10
期刊：
影响因子：
--
通讯作者：
Guan, Xin-Yuan
中科院分区：
文献类型：
--
作者：
Zhu, Ying-Hui;Yang, Fu;Zhang, Shui-Shen;Zeng, Ting-Ting;Xie, Xuan;Guan, Xin-Yuan
Biglycan （BGN）是一种细胞外基质成分，在多种癌症的肿瘤进展中起着至关重要的作用。然而，BGN的表达与临床预后的关系尚未见研究。因此，我们开展本研究以阐明BGN在预测食管鳞状细胞癌（ESCC）患者预后中的作用。本研究采用实时荧光定量PCR和免疫组织化学方法检测170例ESCC组织及46例匹配的邻近非肿瘤组织中BGN的表达。与非肿瘤细胞相比，大约60%的原发性escc中BGN表达上调。BGN高表达与临床分期（P = 0.009）、肿瘤侵袭（P = 0.006）、淋巴结转移（P = 0.046）相关。BGN高表达组的5年疾病特异性生存率（DSS）低于低表达组（36.8% VS 57.4%, P = 0.006）。按病理分期分层分析发现，仅在临床分期较晚期的患者中，DSS的可辨性较明显（P = 0.010）。Cox多因素分析显示，病理N分类（P < 0.001，危险比2.482,95% CI 1.576 ~ 3.909）和BGN表达（P = 0.019，危险比1.713,95% CI 1.092 ~ 2.688）是独立的预后因素。本研究的发现提供了证据，BGN代表了一种潜在的新型预后生物标志物，用于晚期ESCC患者的切除。
Biglycan (BGN), an extracellular matrix component, has been reported to play a crucial role in the tumor progression of various cancers. However, the relation between the expression of BGN and clinical prognosis has not been studied yet. We therefore carry out the present study to elucidate the role of BGN in predicting outcomes of patients with esophageal squamous cell carcinoma (ESCC). In this study, the expression of BGN in 170 cases of ESCC tissues and matched 46 adjacent non-tumorous tissues was measured by quantitative real-time PCR and immunohistochemistry. Upregulation of BGN occurred in approximately 60% of primary ESCCs compared with their non-tumor counterparts. In addition, high expression of BGN was significantly associated with clinical stage (P = 0.009), tumor invasion (P = 0.006) and lymph node metastasis (P = 0.046). The 5-year disease-specific survival (DSS) in high expression of BGN group is poorer than that in low level expression group (36.8% VS 57.4%, P = 0.006). Stratified analysis according to the pathological stage revealed its discernibility on DSS was only pronounced in patients with advanced clinical stage (P = 0.010). Cox multivariate analysis revealed that pathologic N category (P < 0.001; hazard ratio, 2.482, 95% CI, 1.576-3.909) and BGN expression (P = 0.019; hazard ratio, 1.713, 95% CI, 1.092-2.688) were two independent prognostic factors. The findings of the present study provide evidence that BGN represents a potential novel prognostic biomarker for resected ESCC patients in advanced clinical stage.
登录
查看更多内容
影响因子：
4.4
作者：
Bereczki, Erika;Gonda, Szilvia;Santha, Miklos
通讯作者：
Santha, Miklos
DOI：
10.1161/01.atv.9.1.1
发表时间：
1989
期刊：
Arteriosclerosis
影响因子：
--
作者：
Thomas N. Wight
通讯作者：
Thomas N. Wight
影响因子：
4.6
作者：
Lee, J;Lee, KE;Shim, YM
通讯作者：
Shim, YM
DOI：
10.5152/tcb.2013.01
发表时间：
2013-04
期刊：
--
影响因子：
--
作者：
S. Issi
通讯作者：
S. Issi
影响因子：
5.2
作者：
F. Wong;Chi-Ying F. Huang;L. Su;Yu-Chung Wu;Yong-Shiang Lin;J. Hsia;hSin-ting tSai;Sheng-An Lee;Chi-Hung Lin;C. Tzeng;Po-min Chen;Yann-Jan Chen;Shu-Ching Liang;Jin-Mei Lai;C. Yen
通讯作者：
F. Wong;Chi-Ying F. Huang;L. Su;Yu-Chung Wu;Yong-Shiang Lin;J. Hsia;hSin-ting tSai;Sheng-An Lee;Chi-Hung Lin;C. Tzeng;Po-min Chen;Yann-Jan Chen;Shu-Ching Liang;Jin-Mei Lai;C. Yen