The Role of FoxG1 in the Inner Ear.
The Role of FoxG1 in the Inner Ear.
复制标题
FoxG1 在内耳中的作用。
DOI：
10.3389/fcell.2020.614954
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发表时间：
2020
影响因子：
5.5
通讯作者：
Chai R
中科院分区：
文献类型：
--
作者：
Ding Y;Meng W;Kong W;He Z;Chai R
感音神经性耳聋主要是由内耳组织损伤引起的，听力障碍已成为日益严重的全球健康问题。当内耳发育异常或因炎症、耳毒性药物或血液供应障碍而受损时，听觉信号传输受到抑制，导致听力损失。叉头盒G1（FoxG 1）是一种重要的核转录调控因子，与脑、端脑、内耳等组织细胞的分化、增殖、发育和存活有关。以前的研究表明，当FoxG 1表达异常时，内耳毛细胞的发育和功能就会受损。本文从多个方面讨论了FoxG 1在内耳组织中的作用和调节机制--例如对内耳发育的影响、对内耳结构和功能的维持以及在受到各种刺激或损伤时在内耳中的作用--以解释FoxG 1作为治疗听力损失的新靶点的潜在意义。
Sensorineural deafness is mainly caused by damage to the tissues of the inner ear, and hearing impairment has become an increasingly serious global health problem. When the inner ear is abnormally developed or is damaged by inflammation, ototoxic drugs, or blood supply disorders, auditory signal transmission is inhibited resulting in hearing loss. Forkhead box G1 (FoxG1) is an important nuclear transcriptional regulator, which is related to the differentiation, proliferation, development, and survival of cells in the brain, telencephalon, inner ear, and other tissues. Previous studies have shown that when FoxG1 is abnormally expressed, the development and function of inner ear hair cells is impaired. This review discusses the role and regulatory mechanism of FoxG1 in inner ear tissue from various aspects – such as the effect on inner ear development, the maintenance of inner ear structure and function, and its role in the inner ear when subjected to various stimulations or injuries – in order to explain the potential significance of FoxG1 as a new target for the treatment of hearing loss.
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影响因子：
16.2
作者：
Cargnin F;Kwon JS;Katzman S;Chen B;Lee JW;Lee SK
通讯作者：
Lee SK
DOI：
10.1523/jneurosci.5841-11.2012
发表时间：
2012-02-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Dastidar SG;Bardai FH;Ma C;Price V;Rawat V;Verma P;Narayanan V;D'Mello SR
通讯作者：
D'Mello SR
影响因子：
3.7
作者：
Chiola, Simone;Mihn Duc Do;Mallamaci, Antonello
通讯作者：
Mallamaci, Antonello
影响因子：
3.7
作者：
Dou, CL;Li, S;Lai, ES
通讯作者：
Lai, ES
影响因子：
5.3
作者：
Dou, CL;Lee, J;Lai, E
通讯作者：
Lai, E