Respiratory pathogens in children with and without respiratory symptoms.
Respiratory pathogens in children with and without respiratory symptoms.
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患有和没有呼吸道症状的儿童的呼吸道病原体。
DOI：
10.1016/j.jpeds.2008.08.036
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
van der Ent CK
中科院分区：
文献类型：
--
作者：
van der Zalm MM;van Ewijk BE;Wilbrink B;Uiterwaal CS;Wolfs TF;van der Ent CK
调查有呼吸道症状和无呼吸道症状儿童样本中呼吸道病原体的发生情况，并确定年龄和/或合并感染是否会改变呼吸道病原体对症状的影响。在一项前瞻性纵向研究中，每两周对18名儿童进行呼吸道病原体采样，无论呼吸道症状如何。对13种呼吸道病原菌进行聚合酶链反应。如果在采样前1周至采样后1周内没有出现任何呼吸道疾病的症状，则将发作定义为“无症状”。共采集样本230份。在有症状发作的病例中，检测到56%的病原体，而在无症状发作的病例中，这一比例为40% （P = .03）。鼻病毒和冠状病毒在有症状和无症状发作中都是最常见的。在年龄最小的儿童中，9%的病原体阳性发作无症状，而年龄最大的儿童为36% （P = 0.01）。有症状组和无症状组分别有17%和3%的致病菌（P = 0.02）。在没有呼吸道症状的儿童样本中经常检测到呼吸道病原体。有症状的病例多发生在年龄较小的儿童中，并检出1种以上的呼吸道病原体。
To investigate the occurrence of respiratory pathogens in samples from children with and without respiratory symptoms and to identify whether age and/ or coinfections modify the impact of respiratory pathogens on symptoms. In a prospective longitudinal study, 18 children were sampled biweekly for respiratory pathogens, irrespective of respiratory symptoms. Polymerase chain reaction was performed for 13 respiratory pathogens. Episodes were defined “asymptomatic” if no symptoms of any respiratory tract illness were present between 1 week before and 1 week after sampling. A total of 230 samples were collected. In 56% of the symptomatic episodes, a pathogen was detected, compared with 40% of the asymptomatic episodes (P = .03). Rhinovirus and coronaviruses were most prevalent in both symptomatic and asymptomatic episodes. In the youngest children, 9% of the pathogen-positive episodes were asymptomatic, compared with 36% in the oldest children (P = .01). Multiple pathogens were found in 17% of the symptomatic episodes and in 3% of the asymptomatic episodes (P = .02). Respiratory pathogens are frequently detected in samples from children with no respiratory symptoms. Symptomatic cases occurred more often in younger children and with detections of more than 1 respiratory pathogen.
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影响因子：
8.8
作者：
Scheltinga, SA;Templeton, KE;Claas, ECJ
通讯作者：
Claas, ECJ
影响因子：
3.6
作者：
Wilkesmann, Anja;Schildgen, Oliver;Simon, Arne
通讯作者：
Simon, Arne
DOI：
10.1164/ajrccm.159.3.9801052
发表时间：
1999-03-01
影响因子：
24.7
作者：
Rakes, CP;Arruda, E;Heymann, PW
通讯作者：
Heymann, PW
影响因子：
6.4
作者：
Peltola, Ville;Waris, Matti;Hyypia, Timo
通讯作者：
Hyypia, Timo
影响因子：
11.8
作者：
van Gageldonk-Lafeber, AB;Heijnen, MLA;Wilbrink, B
通讯作者：
Wilbrink, B