Increased Extra-axial Cerebrospinal Fluid in High-Risk Infants Who Later Develop Autism.
Increased Extra-axial Cerebrospinal Fluid in High-Risk Infants Who Later Develop Autism.
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DOI：
10.1016/j.biopsych.2017.02.1095
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发表时间：
2017-08-01
影响因子：
10.6
通讯作者：
Infant Brain Imaging Study Network
中科院分区：
文献类型：
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作者：
Shen MD;Kim SH;McKinstry RC;Gu H;Hazlett HC;Nordahl CW;Emerson RW;Shaw D;Elison JT;Swanson MR;Fonov VS;Gerig G;Dager SR;Botteron KN;Paterson S;Schultz RT;Evans AC;Estes AM;Zwaigenbaum L;Styner MA;Amaral DG;Piven J;Hazlett HC;Chappell C;Dager S;Estes A;Shaw D;Botteron K;McKinstry R;Constantino J;Pruett J;Schultz R;Zwaigenbaum L;Elison J;Evans AC;Collins DL;Pike GB;Fonov V;Kostopoulos P;Das S;Gerig G;Styner M;Gu H;Piven J;Infant Brain Imaging Study Network
我们以前曾报道，患有ASD的婴儿在6-24个月大时蛛网膜下腔(即轴外脑脊液)中的脑脊液增加。我们试图在一个更大的、独立的样本中证实和推广这一发现。对343名婴儿进行了ASD高危婴儿的纵向MRI研究，这些婴儿在6个月、12个月和24个月时接受了神经成像，其中221名是ASD的高危婴儿，因为有一个年长的兄弟姐妹患有ASD；122名是低风险的，没有ASD家族史。47名婴儿在24个月时被诊断为ASD，并与174名无ASD的高风险婴儿和122名低风险婴儿进行了比较。发生ASD的婴儿在6个月时轴外脑脊液容量显著高于两个对照组中没有ASD的婴儿(比没有ASD的高危婴儿高18%；Cohen‘s d=0.54)。轴外脑脊液容量在24个月内持续升高(d=0.46)。自闭症症状较重的婴儿在6-24个月时轴外脑脊液的体积更大(6个月时增加24%，d=0.70；24个月时增加15%，d=0.70)。6个月时的轴外脑脊液容量预测24个月时哪些高危婴儿将被诊断为ASD，总体准确率为69%，相应的敏感度和特异度分别为66%和68%，这在单独的样本中得到了完全交叉验证。这项研究证实并扩展了先前的发现，即在6个月时发展为ASD的高危婴儿可检测到轴外脑脊液增加。未来的研究将探讨这种异常是ASD病因的一个促成因素，还是ASD的早期风险标记物。
We previously reported that infants who developed ASD had increased CSF in the subarachnoid space (i.e., extra-axial CSF) from 6–24 months of age. We attempt to confirm and extend this finding in a larger, independent sample. A longitudinal MRI study of infants at-risk for ASD was carried out on 343 infants, who underwent neuroimaging at 6, 12, and 24 months; 221 were high-risk for ASD because of an older sibling with ASD; 122 were low-risk with no family history of ASD. Forty-seven infants were diagnosed with ASD at 24 months and were compared with 174 high-risk and 122 low-risk infants without ASD. Infants who developed ASD had significantly greater extra-axial CSF volume at 6 months compared to both comparison groups without ASD (18% greater than high-risk infants without ASD; Cohen’s d=0.54). Extra-axial CSF volume remained elevated through 24 months (d=0.46). Infants with more severe autism symptoms had an even greater volume of extra-axial CSF from 6–24 months (24% greater at 6 months, d=0.70; 15% greater at 24 months, d=0.70). Extra-axial CSF volume at 6 months predicted which high-risk infants would be diagnosed with ASD at 24 months with an overall accuracy of 69% and corresponding 66% sensitivity and 68% specificity, which was fully cross-validated in a separate sample. This study confirms and extends previous findings that increased extra-axial CSF is detectable at 6 months in high-risk infants who develop ASD. Future studies will address whether this anomaly is a contributing factor to the etiology of ASD or an early risk marker for ASD.
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DOI：
10.1038/nrn3921
发表时间：
2015-08
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Lun MP;Monuki ES;Lehtinen MK
通讯作者：
Lehtinen MK
影响因子：
5.3
作者：
Lahiri DK;Sokol DK;Erickson C;Ray B;Ho CY;Maloney B
通讯作者：
Maloney B
自闭症诊断观察表： 提高诊断有效性的修订算法
影响因子：
3.9
作者：
Gotham, Katherine;Risi, Susan;Lord, Catherine
通讯作者：
Lord, Catherine
影响因子：
16.2
作者：
Lehtinen MK;Zappaterra MW;Chen X;Yang YJ;Hill AD;Lun M;Maynard T;Gonzalez D;Kim S;Ye P;D'Ercole AJ;Wong ET;LaMantia AS;Walsh CA
通讯作者：
Walsh CA
影响因子：
3.9
作者：
Lord, C;Risi, S;Rutter, M
通讯作者：
Rutter, M