Neurodegenerative disorders: insights from the nematode Caenorhabditis elegans.
Neurodegenerative disorders: insights from the nematode Caenorhabditis elegans.
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DOI：
10.1016/j.nbd.2010.05.012
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发表时间：
2010-10
影响因子：
6.1
通讯作者：
Hart AC
中科院分区：
文献类型：
--
作者：
Dimitriadi M;Hart AC
Neurodegenerative diseases impose a burden on society, yet for the most part, the mechanisms underlying neuronal dysfunction and death in these disorders remain unclear despite the identification of relevant disease genes. Given the molecular conservation in neuronal signaling pathways across vertebrate and invertebrate species, many researchers have turned to the nematode Caenorhabditis elegans to identify the mechanisms underlying neurodegenerative disease pathology. C. elegans can be engineered to express human proteins associated with neurodegeneration; additionally, the function of C. elegans orthologs of human neurodegenerative disease genes can be dissected. Herein, we examine major C. elegans neurodegeneration models that recapitulate many aspects of human neurodegenerative disease and we survey the screens that have identified modifier genes. This review highlights how the C. elegans community has used this versatile organism to model several aspects of human neurodegeneration and how these studies have contributed to our understanding of human disease.
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影响因子：
4.2
作者：
Brandt, Roland;Gergou, Aikaterini;Hutter, Harald
通讯作者：
Hutter, Harald
DOI：
10.1073/pnas.90.24.12045
发表时间：
1993-12-15
影响因子：
11.1
作者：
DAIGLE, I;LI, C
通讯作者：
LI, C
影响因子：
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作者：
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通讯作者：
Persichetti, Francesca
DOI：
10.1073/pnas.97.2.571
发表时间：
2000-01-18
影响因子：
11.1
作者：
Conway, KA;Lee, SJ;Lansbury, PT
通讯作者：
Lansbury, PT
影响因子：
5.3
作者：
Bates, EA;Victor, M;Hart, AC
通讯作者：
Hart, AC