Peritoneal nitric oxide is a marker of peritonitis in patients on continuous ambulatory peritoneal dialysis.
Peritoneal nitric oxide is a marker of peritonitis in patients on continuous ambulatory peritoneal dialysis.
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腹膜一氧化氮是连续门诊腹膜透析患者腹膜炎的标志物。
DOI：
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发表时间：
1996
影响因子：
--
通讯作者：
C. C. Huang
中科院分区：
文献类型：
--
作者：
C. W. Yang;T. Hwang;C. Wu;P. Lai;J. Y. Huang;C. ;M. Shyr;C. C. Huang
一氧化氮在介导炎症过程中起重要作用。本研究的目的是评估接受持续性非卧床腹膜透析（CAPD）的患者在腹膜炎期间一氧化氮的产生是否增加，以及与预后的关系。研究人群包括21例发生22次腹膜炎的患者。15例无腹膜炎患者作为对照。硝酸盐通过HPLC测定，亚硝酸盐通过Griess法测定，以反映一氧化氮的产生。在腹膜炎期间和治疗后1周收集6例患者的腹膜透析液流出物和血浆，以研究透析液：血浆比率的变化。在15例患者中，在腹膜炎期间和每3天测量一次亚硝酸盐，持续2周或直到进展性变化正常化。治疗1周后，腹膜炎期间硝酸盐和亚硝酸盐的透析液：血浆比率分别降低26%和41.5%，表明腹膜炎期间腹膜产生一氧化氮。在进化研究中，与对照组相比，观察到细菌性腹膜炎（n = 13）和真菌性腹膜炎（n = 3）中亚硝酸盐峰值水平分别增加了5.1倍和2.5倍。在有效抗生素治疗后，亚硝酸盐逐渐下降至对照水平（9.3 +/- 7.2天），但所需时间长于腹膜透析液流出物中白细胞计数正常化（3.9 +/- 1.9天）。在4例难治性腹膜炎患者中（3例念珠菌感染，1例不动杆菌感染），尽管接受了治疗，但亚硝酸盐水平仍升高2倍，并取出了导管。结论腹膜透析液流出液中亚硝酸盐水平可作为评估腹膜炎CAPD患者治疗效果的指标。
Nitric oxide plays an important role in mediating the inflammatory process. The aim of this study was to evaluate if nitric oxide production was increased during peritonitis in patients receiving continuous ambulatory peritoneal dialysis (CAPD), and the association with the prognosis. The study population comprised 21 patients with 22 episodes of peritonitis. Fifteen patients without peritonitis were controls. Nitrate was measured by HPLC and nitrite by the Griess method, to reflect nitric oxide production. Peritoneal dialysate effluent and plasma were collected from six patients during peritonitis and 1 week after treatment to study changes in dialysate:plasma ratio. In 15 patients, nitrite was measured during peritonitis and every 3 days for 2 weeks or until normalized for evolutional changes. The dialysate:plasma ratios of nitrate and nitrite during peritonitis were reduced 26% and 41.5%, respectively, after 1 week of treatment, indicating the peritoneal production of nitric oxide during peritonitis. In the evolutional study, a 5.1-fold increase of peak nitrite levels in bacterial peritonitis (n = 13) and a 2.5-fold increase in fungal peritonitis (n = 3) were observed compared to controls. Nitrite gradually declined to control levels (9.3 +/- 7.2 days) after effective antibiotic treatment, but took longer than to normalize leukocyte count in the peritoneal dialysate effluent (3.9 +/- 1.9 days). In four patients with refractory peritonitis (Candida infection in three, Acinetobacter infection in one), the nitrite levels remained elevated 2-fold despite treatment, and the catheters were removed. It is concluded that nitrite levels in peritoneal dialysate effluent may serve as a marker to assess treatment efficacy in CAPD patients with peritonitis.
影响因子：
2.9
作者：
GREEN, LC;WAGNER, DA;TANNENBAUM, SR
通讯作者：
TANNENBAUM, SR
影响因子：
4.4
作者：
GREEN, SJ;SCHELLER, LF;NACY, CA
通讯作者：
NACY, CA