Monte Carlo characterization of parallelized fluorescence confocal systems imaging in turbid media.
Monte Carlo characterization of parallelized fluorescence confocal systems imaging in turbid media.
复制标题
浑浊介质中并行荧光共焦系统成像的蒙特卡罗表征。
DOI：
10.1117/1.3194131
复制
发表时间：
2009
影响因子：
3.5
通讯作者：
Gmitro,ArthurF
中科院分区：
文献类型：
--
作者：
Tanbakuchi,AnthonyA;Rouse,AndrewR;Gmitro,ArthurF
我们表征并比较了荧光共焦系统在混浊介质中成像的轴向和横向性能。研究的孔径结构是单个针孔、狭缝、尼普科夫盘和针孔线性阵列。具有并行孔径的系统在临床上使用，因为它们能够实现高速和实时成像。了解它们在高散射组织中的表现非常重要。开发了蒙特卡罗模型来表征代表人体组织的散射介质中的并行系统性能。结果表明，狭缝孔径的横向和轴向性能均下降。相比之下，分析表明，Nipkow 盘或线性针孔阵列等多针孔孔径可以实现几乎相当于单针孔孔径的性能。针对特定组织模型确定了多孔孔径的最佳孔径间距。除了比较孔径配置之外，还研究了组织非辐射吸收、散射各向异性和荧光团浓度对共焦系统横向和轴向性能的影响。
We characterize and compare the axial and lateral performance of fluorescence confocal systems imaging in turbid media. The aperture configurations studied are a single pinhole, a slit, a Nipkow disk, and a linear array of pinholes. Systems with parallelized apertures are used clinically because they enable high-speed and real-time imaging. Understanding how they perform in highly scattering tissue is important. A Monte Carlo model was developed to characterize parallelized system performance in a scattering media representative of human tissues. The results indicate that a slit aperture has degraded performance, both laterally and axially. In contrast, the analysis reveals that multipinhole apertures such as a Nipkow disk or a linear pinhole array can achieve performance nearly equivalent to a single pinhole aperture. The optimal aperture spacing for the multipinhole apertures was determined for a specific tissue model. In addition to comparing aperture configurations, the effects of tissue nonradiative absorption, scattering anisotropy, and fluorophore concentration on lateral and axial performance of confocal systems were studied.
登录
查看更多内容
(±)-7α,8β-二羟基-9β,10β-环氧-7,8,9,10-四氢苯并(a)芘与DNA的反应
影响因子：
6.4
作者：
M. Osborne;P. Brookes;F. Beland;R. Harvey
通讯作者：
R. Harvey
人体细胞中的优先 DNA 修复
影响因子：
64.8
作者：
R. J. Wilkins;R. J. Wilkins;Ronald W. Hart
通讯作者：
Ronald W. Hart
DNA 修复：一种简单的人体细胞酶测定法
影响因子：
2.6
作者：
R. Wilkins
通讯作者：
R. Wilkins
染色体畸变产生的机制。
DOI：
10.1016/0027-5107(73)90060-2
发表时间：
1973
期刊：
Mutation research
影响因子：
--
作者：
M. Bender;H. G. Griggs;P. Walker
通讯作者：
P. Walker
复制后修复：其定义和着色性干皮病细胞株中可能的改变的问题。
DOI：
--
发表时间：
1979
影响因子：
11.1
作者：
S. Park;J. Cleaver
通讯作者：
J. Cleaver