The Impact of Lithium Long-Term Medication on Suicidal Behavior and Mortality of Bipolar Patients
The Impact of Lithium Long-Term Medication on Suicidal Behavior and Mortality of Bipolar Patients
复制标题
长期服用锂药物对双相情感障碍患者自杀行为和死亡率的影响
DOI：
10.1080/13811110590929550
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发表时间：
2005
影响因子：
2.8
通讯作者：
B. Ahrens
中科院分区：
文献类型：
--
作者：
B. Müller;W. Felber;A. Berghöfer;E. Lauterbach;B. Ahrens
摘要本文综述了锂盐长期治疗双相情感障碍患者的抗自杀作用的现有证据和概念。支持锂对双相情感障碍患者自杀预防作用概念的核心研究来自国际研究小组IGSLI，来自瑞典、意大利，最近也来自美国。服用锂的患者自杀风险比不服用锂的患者低8倍。抗自杀作用不一定与锂的发作抑制功效相关联。锂可能挽救的大量生命增加了锂在经济方面的显着好处。锂可以有效降低自杀风险的证据已被整合到现代算法中，以便为个体患者选择最佳的维持治疗。
ABSTRACT The article reviews the existing evidence and the concept of the anti-suicidal effect of lithium long-term treatment in bipolar patients. The core studies supporting the concept of a suicide preventive effect of lithium in bipolar patients come from the international research group IGSLI, from Sweden, Italy, and recently also from the U.S. Patients on lithium possess an eight- time lower suicide risk than those off lithium. The anti-suicidal effect is not necessarily coupled to lithium's episode suppressing efficacy. The great number of lives potentially saved by lithium adds to the remarkable benefits of lithium in economical terms. The evidence that lithium can effectively reduce suicide risk has been integrated into modern algorithms in order to select the optimal maintenance therapy for an individual patient.
影响因子：
17.7
作者：
Solomon, DA;Keller, MB;Endicott, J
通讯作者：
Endicott, J