Pathophysiology and pharmacological management of pulmonary and cardiovascular features of COVID-19.

Pathophysiology and pharmacological management of pulmonary and cardiovascular features of COVID-19.
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DOI:
10.1016/j.yjmcc.2020.12.009
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发表时间:
2021-04
影响因子:
5
通讯作者:
Hadri L
Hadri L
中科院分区:
医学2区
文献类型:
--
作者:
Hamouche W;Bisserier M;Brojakowska A;Eskandari A;Fish K;Goukassian DA;Hadri L

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美国首例新型冠状病毒病2019(新冠肺炎)确诊病例于2020年1月20日报告。截至2020年11月24日,美国确诊新冠肺炎病例近1220万例,死亡人数超过255958人。严重急性呼吸系统综合症冠状病毒2(SARS-CoV-2)的快速传播,其不同寻常和不同的呈现方式强化了新冠肺炎作为主要公共卫生威胁的地位。在这篇综述中,我们旨在1-讨论来自世界各地和美国的不同新冠肺炎患者队列的流行病学数据以及相关的危险因素;2-总结SARS-CoV-2感染的病理生理学以及导致呼吸系统和心血管症状的潜在分子机制;3-重点介绍新冠肺炎的潜在治疗方法和疫苗以及当前的临床试验。
The first confirmed case of novel Coronavirus Disease 2019 (COVID-19) in the United States was reported on January 20, 2020. As of November 24, 2020, close to 12.2 million cases of COVID-19 was confirmed in the US, with over 255,958 deaths. The rapid transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), its unusual and divergent presentation has strengthened the status of COVID-19 as a major public health threat. In this review, we aim to 1- discuss the epidemiological data from various COVID-19 patient cohorts around the world and the USA as well the associated risk factors; 2- summarize the pathophysiology of SARS-CoV-2 infection and the underlying molecular mechanisms for the respiratory and cardiovascular manifestations; 3- highlight the potential treatments and vaccines as well as current clinical trials for COVID-19.
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