The Influence of Extracellular RNA on Cell Behavior in Health, Disease and Regeneration.
The Influence of Extracellular RNA on Cell Behavior in Health, Disease and Regeneration.
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DOI：
10.1007/s40139-017-0121-2
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发表时间：
2017-03
影响因子：
--
通讯作者：
Badylak SF
中科院分区：
文献类型：
--
作者：
Huleihel L;Scarritt ME;Badylak SF
本文概述了细胞外RNA（exRNA）在体内平衡调节、疾病进展和再生中的作用。几种exRNA已被确定为疾病和疾病进展的潜在生物标志物。此外，还讨论了exRNA作为一种治疗方式的潜力。
肺、肝和心脏等器官的纤维化疾病具有一些相同的exRNA，它们在疾病发病机制中起关键作用。尽管人类的再生仅限于少数组织，但小分子RNA（如微小RNA）已被证明参与肝脏和骨骼等组织的再生过程。小分子RNA似乎在愈合与疾病的调节中起到平衡作用。由于小分子RNA对健康至关重要，它们正在多项正在进行的临床试验中作为药物靶点进行研究。临床前研究表明，促进或阻断特定的小分子RNA可提供一种新的治疗方法。
exRNA可用于疾病的检测和治疗。天然和合成的RNA载体正在作为小分子RNA分子的递送方法进行研究。当前和未来的研究可能会使exRNA的应用得到扩展。
An overview of the role of extracellular RNAs (exRNA) in the regulation of homeostasis, disease progression, and regeneration is provided herein. Several exRNAs have been identified as potential biomarkers for disease and disease progression. In addition, the potential of exRNAs as a therapeutic modality is discussed. Fibrotic diseases of the lung, liver, and heart, among other organs share a number of identical exRNAs which play key roles in disease pathogenesis. Though regeneration is limited to only a few tissues in humans, small RNAs (e.g. microRNA) have been shown to be involved in the regenerative process of tissues such as liver and bone. The regulation of healing versus disease appears to be balanced by small RNAs. Because small RNAs are critical to health, they are being investigated as drug targets in multiple ongoing clinical trials. Preclinical studies suggest that promoting or blocking specific small RNAs can provide a novel therapeutic approach. exRNA can be utilized for both detection and treatment of disease. Natural and synthetic RNA carriers are being investigated as delivery methods for small RNA molecules. Current and future investigations are likely to lead to expanded applications for exRNAs.
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影响因子：
3.7
作者：
Barutta F;Tricarico M;Corbelli A;Annaratone L;Pinach S;Grimaldi S;Bruno G;Cimino D;Taverna D;Deregibus MC;Rastaldi MP;Perin PC;Gruden G
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作者：
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