Sympathetic Nervous System Contributions to Hypertension: Updates and Therapeutic Relevance.

Sympathetic Nervous System Contributions to Hypertension: Updates and Therapeutic Relevance.
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DOI:
10.1016/j.cjca.2020.03.003
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发表时间:
2020-05
期刊:
The Canadian journal of cardiology
影响因子:
--
通讯作者:
Stocker SD
Stocker SD
中科院分区:
其他
文献类型:
--
作者:
DeLalio LJ;Sved AF;Stocker SD

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交感神经系统通过中枢神经系统整合神经体液信号和差异调节交感神经输入到特定终末器官的能力,在动脉血压的长期调节中起关键作用。本综述的第1部分将讨论盐敏感性高血压、肥胖性高血压的神经机制,以及既往经验对自主神经网络敏感的能力。本文第二部分重点介绍了治疗顽固性高血压的新进展,包括去肾神经支配和颈动脉压力激活。这两种进展都通过减少交感神经流出来降低动脉血压。我们讨论了潜在的机制和未来的研究领域,以靶向交感神经系统。
The sympathetic nervous system plays a pivotal role in the long-term regulation of arterial blood pressure through the ability of the central nervous system to integrate neurohumoral signals and differentially regulate sympathetic neural input to specific end organs. Part 1 of this review will discuss neural mechanisms of salt-sensitive hypertension, obesity-induced hypertension, and the ability of prior experiences to sensitize autonomic networks. Part 2 of this review focuses on new therapeutic advances to treat resistant hypertension including renal denervation and carotid baroactivation. Both advances lower arterial blood pressure by reducing sympathetic outflow. We discuss potential mechanisms and areas of future investigation to target the sympathetic nervous system.
DOI: 10.14814/phy2.13602
发表时间: 2018-03
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