The case for immunomodulatory approaches in treating HSV encephalitis.
The case for immunomodulatory approaches in treating HSV encephalitis.
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DOI：
10.2217/fvl.12.138
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发表时间：
2013-03-01
期刊：
影响因子：
3.1
通讯作者：
Cantin EM
中科院分区：
文献类型：
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作者：
Ramakrishna C;Openshaw H;Cantin EM
HSV脑炎（HSE）是最常见的散发性病毒性脑炎。尽管安全有效的抗病毒治疗和大大改进的非侵入性诊断程序显着改善了预后，但幸存者的死亡率（约20%）和衰弱性神经系统后遗症仍然高得不可接受。一个令人鼓舞的新发展是，现在的重点正在从单纯的病毒转移到包括考虑HSE病理学基础发展中的宿主对感染的免疫反应。在这篇文章中，作者讨论了最近在实验小鼠模型中进行的研究结果，以及临床报告，这些报告证明了大脑中夸大的宿主炎症反应在HSE发展中的作用，这促使研究人员和临床医生考虑治疗HSE的新治疗方法。作者还讨论了一些研究的结果，这些研究表明免疫调节药物可以高度保护HSE，这支持了HSE中有害宿主炎症反应的作用。HSE小鼠模型中一些免疫调节方法的令人印象深刻的结果强调了临床试验的迫切需要，以严格评估与标准抗病毒治疗相比的抗病毒和免疫调节联合治疗HSE，并且对这种倡议的支持正在获得动力。
HSV encephalitis (HSE) is the most prevalent sporadic viral encephalitis. Although safe and effective antiviral therapies and greatly improved noninvasive diagnostic procedures have significantly improved outcomes, mortality (~20%) and debilitating neurological sequelae in survivors remain unacceptably high. An encouraging new development is that the focus is now shifting away from the virus exclusively, to include consideration of the host immune response to infection in the pathology underlying development of HSE. In this article, the authors discuss results from recent studies in experimental mouse models, as well as clinical reports that demonstrate a role for exaggerated host inflammatory responses in the brain in the development of HSE that is motivating researchers and clinicians to consider new therapeutic approaches for treating HSE. The authors also discuss results from a few studies that have shown that immunomodulatory drugs can be highly protective against HSE, which supports a role for deleterious host inflammatory responses in HSE. The impressive outcomes of some immunomodulatory approaches in mouse models of HSE emphasize the urgent need for clinical trials to rigorously evaluate combination antiviral and immunomodulatory therapy in comparison with standard antiviral therapy for treatment of HSE, and support for such an initiative is gaining momentum.
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影响因子：
11.2
作者：
DAVIS, LE;JOHNSON, RT
通讯作者：
JOHNSON, RT
影响因子：
3.8
作者：
ELLERMANNERIKSEN, S;SOMMERLUND, M;MOGENSEN, SC
通讯作者：
MOGENSEN, SC
影响因子：
3.8
作者：
ELLERMANNERIKSEN, S;JUSTESEN, J;MOGENSEN, SC
通讯作者：
MOGENSEN, SC
影响因子：
5.4
作者：
Cantin, E;Tanamachi, B;Clarke, K
通讯作者：
Clarke, K
影响因子：
30.5
作者：
通讯作者：
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