Conservation of notochord gene expression across chordates: insights from the Leprecan gene family.
Conservation of notochord gene expression across chordates: insights from the Leprecan gene family.
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DOI：
10.1002/dvg.20406
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发表时间：
2008-11
期刊：
影响因子：
1.5
通讯作者：
Di Gregorio, Anna
中科院分区：
文献类型：
--
作者：
Capellini, Terence D.;Dunn, Matthew P.;Passamaneck, Yale J.;Selleri, Licia;Di Gregorio, Anna
脊索是脊索动物的一个决定性特征，T-box转录因子Brachyury已被证明是所有脊索动物脊索发育所需的。在海鞘中，至少有44个脊索基因已被确定为Brachyury的真正转录靶标。我们研究了一个亚组的小鼠直系同源玻璃海鞘短尾目靶基因在脊索的胚胎表达，以评估其在整个脊索动物进化的保护。我们专注于分析Leprecan基因家族，该基因家族在小鼠中由三个基因组成，而不是单拷贝的Ciona基因。我们发现所有三个小鼠Leprecan基因在脊索中表达。此外，Leprecan在C.脊髓灰质炎局限于脊索，其小鼠直向同源物的表达包括背根神经节、肢芽、鳃弓和发育中的肾脏。这些结果对脊索动物的进化和发育具有重要意义。
The notochord is a defining character of the chordates, and the T-box transcription factor Brachyury has been shown to be required for notochord development in all chordates examined. In the ascidian Ciona intestinalis, at least 44 notochord genes have been identified as bona fide transcriptional targets of Brachyury. We examined the embryonic expression of a subset of murine orthologs of Ciona Brachyury target genes in the notochord to assess its conservation throughout chordate evolution. We focused on analyzing the Leprecan gene family, which in mouse is composed of three genes, as opposed to the single-copy Ciona gene. We found that all three mouse Leprecan genes are expressed in the notochord. Additionally, while Leprecan expression in C. intestinalis is confined to the notochord, expression of its mouse orthologs includes dorsal root ganglia, limb buds, branchial arches, and developing kidneys. These results have interesting implications for the evolution and development of chordates.
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影响因子：
2.7
作者：
Hotta, K;Takahashi, H;Satoh, N
通讯作者：
Satoh, N
影响因子：
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作者：
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DOI：
10.1073/pnas.90.15.7288
发表时间：
1993-08-01
影响因子：
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作者：
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通讯作者：
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