Glucose-dependent insulinotropic polypeptide stimulates the proliferation of colorectal cancer cells.
Glucose-dependent insulinotropic polypeptide stimulates the proliferation of colorectal cancer cells.
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DOI：
10.1016/j.regpep.2010.04.005
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发表时间：
2010-08-09
影响因子：
--
通讯作者：
Wolfe, M. Michael
中科院分区：
文献类型：
--
作者：
Prabakaran, Daniel;Wang, Baogui;Feuerstein, Joseph D.;Sinclair, Jennifer A.;Bijpuria, Priti;Jepeal, Lisa I.;Wolfe, M. Michael
尽管大量的流行病学研究提供了令人信服的证据表明肥胖个体中结直肠癌（CRC）的患病率增加，但所涉及的确切机制尚未阐明。葡萄糖依赖性促胰岛素多肽（GIP）是一种胃肠道调节肽，其主要生理作用是刺激餐后胰腺胰岛素分泌。像胰岛素一样，GIP与进化过程中发生的营养效率提高有关。它的表达在肥胖中增加，因此我们开始研究GIP是否可能有助于肥胖相关CRC的发病机制。RT-PCR和Western分析证实了GIP受体（GIPR）在几种人CRC细胞系中的存在。GIP以浓度依赖性方式刺激小鼠CRC细胞系MC-26细胞的增殖。Western分析表明，GIP诱导的几个下游信号分子的活动，已知参与细胞增殖的浓度和时间依赖性的方式。这些研究表明，CRC中GIP受体的存在可能使配体结合成为可能，并在这样做时刺激CRC细胞增殖。GIP的过度表达，这发生在肥胖症，从而可能有助于提高在肥胖症中观察到的致癌率。
Although numerous epidemiological studies have provided convincing evidence for an increase in the prevalence of colorectal cancer (CRC) in obese individuals, the precise mechanisms involved have not been elucidated. Glucose-dependent insulinotropic polypeptide (GIP) is a gastrointestinal regulatory peptide whose primary physiologic role is to stimulate postprandial pancreatic insulin secretion. Like insulin, GIP has been linked to enhanced nutrient efficiency, which occurred during the course of evolution. Its expression is increased in obesity, and we thus initiated studies to examine whether GIP might contribute to the pathogenesis of obesity-related CRC. RT-PCR and Western analysis demonstrated the presence of the GIP receptor (GIPR) in several human CRC cell lines. GIP stimulated the proliferation of MC-26 cells, a mouse CRC cell line, in a concentration-dependent manner. Western analysis showed that GIP induced the activity of several downstream signaling molecules known to be involved in cellular proliferation in a concentration- and time-dependent manner. These studies indicate that the presence of GIP receptors in CRC may enable ligand binding and, in so doing, stimulate CRC cell proliferation. The overexpression of GIP, which occurs in obesity, might thereby be contributing to the enhanced rate of carcinogenesis observed in obesity.
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影响因子：
29.4
作者：
Nakata, H;Wang, SL;Tillotson, LG
通讯作者：
Tillotson, LG
影响因子：
4.8
作者：
Althage, Matthew C.;Ford, Eric L.;Wice, Burton M.
通讯作者：
Wice, Burton M.
影响因子：
158.5
作者：
Calle, EE;Rodriguez, C;Thun, MJ
通讯作者：
Thun, MJ
DOI：
10.1016/0021-9681(79)90119-x
发表时间：
1979-01-01
期刊：
JOURNAL OF CHRONIC DISEASES
影响因子：
--
作者：
LEW, EA;GARFINKEL, L
通讯作者：
GARFINKEL, L
影响因子：
4.2
作者：
Giovannucci, E
通讯作者：
Giovannucci, E