Infusion pressure and pain during microneedle injection into skin of human subjects.
Infusion pressure and pain during microneedle injection into skin of human subjects.
复制标题
微针注射过程中的输注压力和疼痛为人类受试者的皮肤。
DOI：
10.1016/j.biomaterials.2011.05.061
复制
发表时间：
2011-10
期刊：
影响因子：
14
通讯作者：
Prausnitz, Mark R.
中科院分区：
文献类型：
--
作者：
Gupta, Jyoti;Park, Sohyun S.;Bondy, Brian;Felner, Eric I.;Prausnitz, Mark R.
使用中空微针输注到皮肤中提供了皮下注射针注射的有吸引力的替代方案。然而，流体力学和疼痛与注射到皮肤使用微针尚未详细研究。在这里，我们报告了微针插入皮肤的深度、部分针回缩、流体输注流速和透明质酸酶的共同给药对基于微针的盐水输注期间的输注压力以及对人类受试者的相关疼痛的影响。输注高达几百微升的液体需要几百mmHg的压力，几乎没有疼痛，并且对输注参数的依赖性很弱。输注高达1 mL的较大体积需要高达几千mmHg的压力，但通常仍然引起轻微疼痛。一般来说，注射更大体积的液体需要更大的压力，并且施加更大的压力会导致更多的疼痛，尽管其他实验参数也起了重要作用。在皮内微针组中，微针长度几乎没有影响;微针回缩降低了输注压力，但增加了疼痛;较低的流速降低了输注压力，并保持较低的疼痛;使用透明质酸酶也降低了输注压力，并保持较低的疼痛。我们的结论是，微针提供了一种简单的方法，可以将液体注入皮肤，几乎没有疼痛。
Infusion into skin using hollow microneedles offers an attractive alternative to hypodermic needle injections. However, the fluid mechanics and pain associated with injection into skin using a microneedle have not been studied in detail before. Here, we report on the effect of microneedle insertion depth into skin, partial needle retraction, fluid infusion flow rate and the co-administration of hyaluronidase on infusion pressure during microneedle-based saline infusion, as well as on associated pain in human subjects. Infusion of up to a few hundred microliters of fluid required pressures of a few hundred mmHg, caused little to no pain, and showed weak dependence on infusion parameters. Infusion of larger volumes up to 1 mL required pressures up to a few thousand mmHg, but still usually caused little pain. In general, injection of larger volumes of fluid required larger pressures and application of larger pressures cause more pain, although other experimental parameters also played a significant role. Among the intradermal microneedle groups, microneedle length had little effect; microneedle retraction lowered infusion pressure but increased pain; lower flow rate reduced infusion pressure and kept pain low; and use of hyaluronidase also lowered infusion pressure and kept pain low. We conclude that microneedles offer a simple method to infuse fluid into the skin that can be carried out with little to no pain.
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DOI：
10.1073/pnas.2331316100
发表时间：
2003-11-25
影响因子：
11.1
作者：
McAllister, DV;Wang, PM;Prausnitz, MR
通讯作者：
Prausnitz, MR
影响因子：
2.8
作者：
Haq, M. I.;Smith, E.;Birchall, J. C.
通讯作者：
Birchall, J. C.
影响因子：
46.9
作者：
Prausnitz, Mark R.;Langer, Robert
通讯作者：
Langer, Robert
DOI：
10.4161/hv.6.4.10961
发表时间：
2010-04-01
期刊：
HUMAN VACCINES
影响因子：
--
作者：
Arnou, Robert;Eavis, Patrick;Weber, Francoise
通讯作者：
Weber, Francoise
影响因子：
6.6
作者：
Frost, Gregory I.
通讯作者：
Frost, Gregory I.