SARS-CoV-2 one year on: evidence for ongoing viral adaptation.
SARS-CoV-2 one year on: evidence for ongoing viral adaptation.
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DOI：
10.1099/jgv.0.001584
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Barclay WS
中科院分区：
文献类型：
--
作者：
Peacock TP;Penrice-Randal R;Hiscox JA;Barclay WS
SARS-CoV-2被认为起源于人畜共患病的溢出事件。人类感染导致多种后果，从无症状病例到COVID-19疾病，其可能具有显著的发病率和死亡率，截至2021年1月，全球有超过200万例确诊死亡。大流行一年多来，测序分析表明，随着SARS-CoV-2病毒继续在人群中广泛传播，该病毒的变种正在被选择。SARS-CoV-2内遗传变异的主要驱动因素是由聚合酶错误引起的单核苷酸多态性（SNP）、潜在的宿主因子驱动的RNA修饰以及由病毒RNA合成的不连续性质引起的插入/缺失（indels）。虽然许多突变代表中性的“遗传漂变”或已迅速消失，但一个子集可能影响病毒特性，如病毒的传播性、致病性、宿主范围和抗原性。在这篇综述中，我们总结了目前SARS-CoV-2的遗传变化程度，特别是最近出现的令人担忧的变异，并考虑了这种病毒进化的表型后果，可能会影响未来的大流行的轨迹。
SARS-CoV-2 is thought to have originated in the human population from a zoonotic spillover event. Infection in humans results in a variety of outcomes ranging from asymptomatic cases to the disease COVID-19, which can have significant morbidity and mortality, with over two million confirmed deaths worldwide as of January 2021. Over a year into the pandemic, sequencing analysis has shown that variants of SARS-CoV-2 are being selected as the virus continues to circulate widely within the human population. The predominant drivers of genetic variation within SARS-CoV-2 are single nucleotide polymorphisms (SNPs) caused by polymerase error, potential host factor driven RNA modification, and insertion/deletions (indels) resulting from the discontinuous nature of viral RNA synthesis. While many mutations represent neutral ‘genetic drift’ or have quickly died out, a subset may be affecting viral traits such as transmissibility, pathogenicity, host range, and antigenicity of the virus. In this review, we summarise the current extent of genetic change in SARS-CoV-2, particularly recently emerging variants of concern, and consider the phenotypic consequences of this viral evolution that may impact the future trajectory of the pandemic.
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影响因子：
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DOI：
10.1016/j.jacbts.2020.10.003
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JACC. Basic to translational science
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