Mapping of Human FOXP2 Enhancers Reveals Complex Regulation.
Mapping of Human FOXP2 Enhancers Reveals Complex Regulation.
复制标题
DOI：
10.3389/fnmol.2018.00047
复制
发表时间：
2018
影响因子：
4.8
通讯作者：
Vernes SC
中科院分区：
文献类型：
--
作者：
Becker M;Devanna P;Fisher SE;Vernes SC
Mutations of the FOXP2 gene cause a severe speech and language disorder, providing a molecular window into the neurobiology of language. Individuals with FOXP2 mutations have structural and functional alterations affecting brain circuits that overlap with sites of FOXP2 expression, including regions of the cortex, striatum, and cerebellum. FOXP2 displays complex patterns of expression in the brain, as well as in non-neuronal tissues, suggesting that sophisticated regulatory mechanisms control its spatio-temporal expression. However, to date, little is known about the regulation of FOXP2 or the genomic elements that control its expression. Using chromatin conformation capture (3C), we mapped the human FOXP2 locus to identify putative enhancer regions that engage in long-range interactions with the promoter of this gene. We demonstrate the ability of the identified enhancer regions to drive gene expression. We also show regulation of the FOXP2 promoter and enhancer regions by candidate regulators – FOXP family and TBR1 transcription factors. These data point to regulatory elements that may contribute to the temporal- or tissue-specific expression patterns of human FOXP2. Understanding the upstream regulatory pathways controlling FOXP2 expression will bring new insight into the molecular networks contributing to human language and related disorders.
登录
查看更多内容
影响因子：
8.8
作者：
Core LJ;Waterfall JJ;Gilchrist DA;Fargo DC;Kwak H;Adelman K;Lis JT
通讯作者：
Lis JT
影响因子：
9.8
作者：
Feuk, Lars;Kalervo, Aino;Hannula-Jouppi, Katariina
通讯作者：
Hannula-Jouppi, Katariina
影响因子：
46.9
作者：
Ernst J;Kellis M
通讯作者：
Kellis M
DOI：
10.1073/pnas.1411270111
发表时间：
2015-06-02
影响因子：
11.1
作者：
Adegbola, Abidemi A.;Cox, Gerald F.;Chess, Andrew
通讯作者：
Chess, Andrew
影响因子：
16.2
作者：
Hevner, RF;Shi, LM;Rubenstein, JLR
通讯作者：
Rubenstein, JLR